Blockade of renin-angiotensin system downregulates tissue factor induced by monocyte-adhesion to endothelial cells via suppressing ICAM-1 and Ca^<2+> signaling

スポンサーリンク

概要

• 論文の詳細を見る
• 社団法人日本循環器学会の論文
• 2002-03-31

著者

• Ohkawara Hiroshi

  First Department Of Internal Medicine Fukushima Medical University

• Ishibashi Toshiyuki

  First Department Of Internal Medicine Fukushima Medical University

• Sakamoto Takayuki

  First Department of Internal Medicine, Fukushima Medical University

• Maruyama Yukio

  First Department Of Internal Medicine Fukushima Medical College

• Nagata Kenji

  First Department Of Internal Medicine Fukushima Medical University

• Sakamoto Takayuki

  First Department Of Internal Medicine Fukushima Medical University

• Ohkawara Hirosi

  First Department of Internal Medicine, Fukushima Medical University

• Sugimoto Kohichi

  First Department of Internal Medicine, Fukushima Medical University

• Ishibashi Toshiyuki

  First Department Of Fumusima Medical University

関連論文

• OE-296 Metabolic Regulation of Coronary Vascular Tone : Role of Hydrogen Peroxide, Adenosine 5'-diphosphate, and Angiotensin(OE50,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Oral Presentation (English),The 73rd Annual Scientific M
• Attenuation of Cardioprotective Effect by Postconditioning in Coronary Stenosed Rat Heart and Its Restoration by Carvedilol
• PJ-294 Quantitative Analysis of Change in Early Diastolic Strain Rate for Exercise Induced Myocardial Ischemia: Comparison with TC^ Myocardial Scintigraphy(Echo/Doppler(14)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanes
• PE-533 Short-term Cholesterol-lowering Therapy Improves Myocardial Microvascular Dysfunction in Patients with Hypercholesterolemia : Evaluation of Myocardial Blood Velocity by Myocardial Contrast Echocardiography(Echo/Doppler(10)(I),Poster Session(English
• PE-388 Atorvastatin Blocks an Advanced Glycation End Products (AGE) : Receptor for AGE(RAGE) Axis in Diabeteic Vascular Responses(Cardiovascular pharmacology, basic/clinical(04)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese
• PE-086 New Insights into Oxidized LDL-induced RhoA and Rac1 Activation by an LOX-1-MT1-MMP Axis in Endothelial Dysfunction(Endothelium(02)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-248 New Developed Powerful Tool for Detecting of Exercise Induced Myocardial Dysfunction : Assessment of Early Diastolic Strain Rate(Echo / Doppler(04)(I),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Socie
• Attenuation of Diastolic Heart Failure and Life-Threatening Ventricular Tachyarrhythmia After Peripheral Blood Stem Cell Transplantation Combined With Cardioverter-Defibrillator Implantation in Myeloma-Associated Cardiac Amyloidosis
• Prediction of Remote Left Ventricular Volumes and Functions After Acute Myocardial Infarction With Successful Coronary Intervention
• DPJ-072 Regulation of Coronary Vascular Tone via Redox Modulation in the Alpha1-Adrenergic-Angiotensin-Endothelin Axis of the Myocardium(DPJ12,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Digital Poster Session (Japanese),The 73rd
• Unexpected Worsening of Mitral Regurgitation After Surgical Closure of Atrial Septal Defect
• Involvement of von Willebrand Factor and PGI_2 in Platelet Binding to a Partially Denuded Endothelial Monolayer
• RhoA and Rac1 Changes in the Atherosclerotic Lesions of WHHLMI Rabbits
• PE-493 Rapid Improvement of Impaired Endothelium-Dependent Vasodilation and Rac1/NADPH Oxidase-Derived ROS Generation in Vivo by Pravastatin(PE083,Cardiovascular Pharmacology (Basic), Cost-health Care System/DPC/Laws (H),Poster Session (English),The 73rd
• OE-091 Involvement of Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) in Advanced Glycation End Products (AGE)/RAGE-Signaling Pathways(OE16,Diabetes (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-664 LOX-1 plays a crucial role in RhoA-and Rac1-dependent signaling through Gi induced by oxidized low-density lipoprotein in endothelial cells(Molecular biology, vascular-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-559 Pravastatin Rapidly Prevents Thrombin-induced Vasoconstriction and NADPH Oxidase-dependent ROS Generation in vivo : Implications for Beneficial Effect(Cardiovascular pharmacology, basic/clinical-5, The 71st Annual Scientific Meeting of the Japanese
• PJ-216 Receptor for Advanced Glycation End Products (RAGE) Plays a Crucial Role in Atherosclerosis(Atherosclerosis, basic-9, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-067 New Insights into Regulation of Diabetic Vascular Remodeling by an MT1-MMP-RAGE axis(Atherosclerosis, basic-8, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-197 RhoA-Dependent PAI-1 Gene Exprssion Induced in Endothelial Cells by Monocyte Adhesion is Mediated Via Geranylgeranyl Transferase I and Ca^ Signaling(Atherosclerosis, basic-3, The 71st Annual Scientific Meeting of the Japanese Circulation Societ
• PJ-475 Crucial Role of Geranylgeranyl Transferase I in AGE-Induced Gene Expression in Diabetes(Atherosclerosis, basic-5 (H) PJ80,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-473 A Novel Role of LOX-1 in Monocyte Adhesion-Induced Gene Expression via Redox-Sensitive and Ca^ Signaling Pathways in Endothelial Cells(Atherosclerosis, basic-5 (H) PJ80,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of
• PJ-102 MT1-MMP-RAGE Axis in Regulation of Advanced Glycation End Products (AGEs)-Dependent Redox-sensitive Signaling(Molecular biology, vascular-3 (H) PJ17,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulatio
• PE-003 Increased Expression of Matrix Metalloproteinase-9 and Apoptosis Induced by Advanced Glycation Endproducts in Type 2 Diabetes : Implications for Plaque Instability(Acute coronary syndrome, basic/clinical-4 (IHD) PE1,Poster Session (English),The 70t
• OJ-262 A Role of Reactive Oxygen Species in Coronary Spasm(Coronary circulation, basic/clinical-2 (IHD) OJ44,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-164 Essential Role of Rapid Geranylgeranylation from Unprocessed RhoA in RhoA Activation and Increase in Unprocessed RhoA in Atherosclerosis(Endothelium-2 (H) OJ28,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japan
• Monocyte Adhesion to Endothelial Cells Activates p47phox/NF-kB via Renin-Angiotensin System(RAS), Resulting in Gene Induction of MCP-1, ICAM-1 and Tissue Factor (Atherosclerosis, Basic 9 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulatio
• Activation of CCR2 by MCP-1 Accelerates TF Expression via Ca2+ Influx in Monocyte Adhesion to Nitric Oxide (NO)-Impaired Endothelial Cells(Atherosclerosis, Basic 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Blockade of Renin-angiotensin System (RAS) Inhibits Oxidized LDL-induced Superoxide Generation by Suppressing NADPH Oxidase Component Nox-4, p47 phox and Rac(Atherosclerosis, Basic 8 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation So
• Membrane type 1 Metalloproteinase (MT1-MMP) is Involved in the RhoA-dependent eNOS Downergulation Induced by Oxidized LDL in Endothelial Cells(Atherosclerosis, Basic 4 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Difference in Early Effects of Statin Therapy on Coronary and Forearm Flow Reserve in Postmenopausal Hypercholesterolemic Women
• PJ-250 Difference in Short-term Effects of Statin Therapy on Coronary and Forearm Flow Reserve in Postmenopausal Hypercholesterolemic Japanese Women(Echo/Doppler-16, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-170 Assessment of Microvascular Dysfunction by Myocardial Blood Velocity in Patients with Hyperlipoproteinemia(Echo / Doppler-06, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-275 Improvement of Microvascural Dysfunction by Cholesterol-lowering Therapy in Patients with Hypercholesterolemia is Different between Forearm and Coronary Arterial Beds(Echo/Doppler-5 (I) OJ46,Oral Presentation (Japanese),The 70th Anniversary Annual
• OJ-171 Myocardial Flow Velocity at Rest Predicts Improvement of Systolic Function in Patients with Dilated Cardiomyopathy(Echo/Doppler-4 (I) OJ29,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Socie
• A Positive Correlation of the Grade of Endothelial Dysfunction between Forearm and Coronary Arterial Beds in Patients with Hyperlipidemia (Peripheral Circulation/Vascular Disease 6 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Societ
• Myocardial Flow Velocity at Rest Predicts Functional Prognosis of Dilated Cardiomyopathy(Echo/Doppler 16 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• PE-188 The Detection of Microheterogeneity in Myocardial Perfusion by Myocardial Contrast Echocardiography(Echo/Doppler 8 (I) : PE32)(Poster Session (English))
• Detection of microvascular dysfunction by intravenous contrast echocardiography in patients with dilated cardiomyopathy
• Continuous Observation of Superoxide Generation in an In-Situ Ischemia-Reperfusion Rat Lung Model
• P433 CORONARY MICROVASCULAR FUNCTION AND THALLIUM-201 SPECT FINDINGS IN PATIENTS WITH EXERCISE INDUCED ISCHEMIC ST CHANGES BUT NORMAL CORONARY ARTERIES
• 0016 Predictive value of sequential quantitative exercise thallium-201 scintigraphies for restenosis in asymptomatic patients after successful percutaneous transluminal coronary angioplasty
• -P330- THE TIME COURSE OF SUPEROXIDE GENERATION IN IN SITU ISCHEMIA-REPERFUSED RAT LUNG(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• The production of superoxide in short time ischemia-reperfused in vivo rat heart
• Mast Cells Contribute to Flow Restoration by Bone Marrow Cell Transplantation in Rats With Ischemic Limbs
• Microvascular Thrombosis in the Hepatic Vein of a Patient with Paroxysmal Nocturnal Hemoglobinuria
• Role of Ca^ Influx in Tissue Factor Expression in Monocyte Adhesion to Endothelial Cells
• Vasoconstrictive Response in the Vascular Beds of the Non-Exercising Forearm During Leg Exercise in Patients With Mild Chronic Heart Failure
• PJ-711 Antioxidant and Anti-hypertrophic Effects of Carbon Monoxide is Mediated via the Suppression of Akt Activation in Angiotensinlltreated LDL-receptor Knockout Mice(Vascular smooth muscle-2, The 71st Annual Scientific Meeting of the Japanese Circulati
• Inhibition of Matrix Metalloproteases (MMPs) Suppresses Rac/NADPH Oxidase-derived Reactive Oxygen Species (ROS) Generation in Oxidized Low Density Lipoprotein-stimuleted Endothelial Cells(Atherosclerosis, Basic 4 (IHD), The 69th Annual Scientific Meeting
• Therapeutic Effect of Intravenous Administration of Statin on eNOS Downregulation and ROS Generation in Response to Thrombin in Vivo(Cardiovascular Pharmacology, Basic/Clinical 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-582 Intravenous administration of statin prevents RhoA activation-triggered eNOS downregulation and reactive oxygen species induced by thrombin in rats(Cardiovascular Pharmacology, Basic/Clinical 5 (H) : PJ98)(Poster Session (Japanese))
• PE-216 Mechanism and Role of Geranylgeranylation in RhoA Activation in Endothelial Dysfunction(Metabolism/Biochemistry/Energetics 1 (IHD) : PE37)(Poster Session (English))
• OE-118 Inhibition of Matrix Metalloproteinases (MMPs) Suppresses the RhoA-dependent eNOS Downergulation Induced by Oxidized LDL in Endothelial Cells(Atherosclerosis, Basic 1 (IHD) : OE14)(Oral Presentation (English))
• Rho Activation and Extracellular Signal-Regulated Kinase (ERK) Downregulation Are Crucial for eNOS Downregulation in Monocyte Adhesion to Endothelial Cells
• Thrombin-lnduced Downregulation of Endothelial Nitric Oxide Synthase (eNOS) via Rho Activation in Human Endothelial Cells :Involvement of Geranylgeranyl Transferase Activation
• Thrombin-Stimulated Ca^ Signaling Mediated via RhoA Activationin Tissue Factor (TF) and Plasminogen Activator Inhibitor-1 (PAI-1) Synthesis in Endothelial Cells
• RhoA Activation Plays an Integral Role in Tissue Factor (TF) Gene Expression
• Oxidized LDL Downregulates Endothelial Nitric Oxide Synthase (eNOS) via Rapid RhoA Activaion in Endothelial Cells
• PE-322 SPECT/CTCA Fusion Image is Useful for the Diagnosis of Coronary Artery Stenosis with Calcification(PE054,CT/MRI (New Technology) (I),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• DPJ-024 Serum NT-proBNP Level for Diagnosis of Diastolic Heart Failure in Japanese Population(DPJ04,Heart Failure (Diagnosis) (M),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• OE-027 Adaptive Servo Ventilation Improves Cardiac Function in Heart Failure Patients with Cheyne-Stokes Respiration(OE05,Obesity/SAS (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Role of Advanced Glycation End Products (AGEs) in Increased Matrix Metalloproteinases (MMPs) Expression in Patients with Diabetes Mellitus (DM)(Diabetes/Obesity 9 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-039 Correlation between Atherosclerotic Plaque Instability and Matrix Metalloproteinase(MMPs) Expression in Autopsy Cases of Diabetes Mellitus(DM)(Diabetes/Obesity 1 (H) : OJ5)(Oral Presentation (Japanese))
• PJ-833 Assessment of Left Atrial Function : Comparison of MDCT and Echocardiography(CT / DSA(11)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-252 Metabolic Regulation of Coronary Vascular Tone : Role of Hydrogen Peroxide, Purinergic Component, and Angiotensin.(Coronary circulation, basic/clinical(03)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation
• PJ-248 Regulation of Coronary Vascular Tone via Redox Modulation in the Alpha-Adrenergic-Angiotensin-Endothelin Axis of the Myocardium(Coronary circulation, basic/clinical(03)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanes
• PE-067 Comparative Analysis of the Incidence of Metabolic Syndrome among Different Age Groups in the Patients with Coronary Artery Disease(Diabetes/Obesity/Metabolic syndrome(04)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanes
• PJ-217 Monocyte Adhesion Induces Gene Expression Mediated via LOX-1-dependent Signaling Pathways in Endothelial Cells(Atherosclerosis, basic-9, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Low Serum Ferritin Levels as a Clue to Colonic Cancer Detection in Two Patients with Coronary Artery Disease : A Case Report
• Expression of Cytokine and Adhesion Molecule mRNA in Atherectomy Specimens From Patients With Coronary Artery Disease
• IS112 Granulocyte-macrophage colony-stimulating factor alters cellular and extracellular composition of atherosclerotic lesions and reduces atherosclerosis in atherogenic rabbits
• OE-031 Characteristics of Hospitalized Heart Failure Patients Who Have Also Chronic Kidney Disease(Heart failure, clinical-01, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Very low density lipoprotein receptor mRNA in monocytes is upregulated by hypoxia
• PJ-583 Pravastatin Inhibits the Generation of Reactive Oxygen Species Induced byThrombin in Endothelial Cells and Cardiomyocytes(Cardiovascular Pharmacology, Basic/Clinical 5 (H) : PJ98)(Poster Session (Japanese))
• OJ-217 Role of geranylgeranyl transferase activation and Ca^ Signaling in Plasminogen Activator Inhibitor-1 Expression in Endothelial Cells Triggered by Monocyte Adhesion(Blood Coagulation/Fibrinolysis (IHD) : OJ24)(Oral Presentation (Japanese))
• OJ-049 Nicorandil Suppresses Thrombin-induced Tissue Factor (TF) and Plasminogen Activator Inhibitor-1 Expression (PAI-1) via Blockade of Ca^ influx in Endothelial Cells(Antithrombofic Ttherapy (H) : OJ6)(Oral Presentation (Japanese))
• OE-274 HMG-CoA Reductase Inhibitor (Statin) Possibly Functions as Ca^ Antagonist in Endothelial Cells(Cardiovascular Pharmacology, Basic/Clinical 1 (H) : OE34)(Oral Presentation (English))
• Blockade of Renin-Angiotensin System Downregulates TF in Monocyte Adhesion to Endothelial Cells via Suppressing ICAM-1, MCP-1 Expression and Ca^ Signaling
• Role of Hydrogen Peroxide (H_2O_2) on Non Selective Cation Current on Endothelial Cells Stimulated by Lysophosphatidylcholine (LPC)
• HMG-CoA Reductase Inhibitors (Statins) Suppress Nonselective Cation Current Induced by Lysophosphatidylcholine in Endothelial Cells
• Inhibition of Rho/Rho-kinase signaling rescues the downregulated eNOS synthesis induced by thrombin in endothelial cells
• Thrombin-stimulated Ca^ mobilization mediated via Gi through Rho/Rho-kinase is involved in tissue factor (TF) synthesis in endothelial cells (ECs)
• Comprehensive Analyses of Arrhythmogenic Substrates and Vulnerability to Ventricular Tachycardia in Left Ventricular Hypertrophy in Salt-Sensitive Hypertensive Rats
• Different Contribution of Apoptosis to the Antiproliferative Effects of L-Arginine, Enalapril and Losartan on Neointimal Growth Inhibition After Balloon Arterial Injury
• PJ-009 Endothelin Type A Receptor Antagonist Has a Protective Effect on Coronary Microvascular Spasm Induced by Repeated Epicardial Endothelial Injury(Coronary circulation, basic/clinical-4 (IHD) PJ2,Poster Session (Japanese),The 70th Anniversary Annual S
• PJ-227 Different anti-ischemic heart failure effect of L-arginine or tetrahydrobiopterin and nitrate through their effects on ischemia-induced oxidative stress generation(Heart Failure, Basic 2 (M) : PJ38)(Poster Session (Japanese))
• OJ-420 Protective effect of chronic endothelin type A receptor antagonist on coronary microvascular spasm induced by repeated epicardial endothelial injury.(Endothelium/NO 5 (H) : OJ51)(Oral Presentation (Japanese))
• FRS-068 Chronic endothelin type A receptor antagonist has a protective effect on coronary spasm induced by repeated epicardial endothelial injury.(Atherosclerosis (IHD) : FRS8)(Featured Research Session (English))
• THE INHIBITORY EFFECT OF ENALAPRIL ON THE NEOINTIMAL FORMATION AFTER ARTERIAL INTIMAL INJURY VIA APOPTOSIS
• Blockade of Endothelin-1 Prevents Coronary Spasm Induced by repeated Epicardial Endothelial Injury in a Pig Model (Endothelium/NO 3 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Chronic Endothelin Type A Antagonist is Effective to Prevent Coronary Microvascular Spasm Induced by Repeated Endothelial Injury(Coronary Circulation, Basic/Clinical 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Effects of Granulocyte-Macrophage Colony-Stimulating Factor on the Levels of VLDL and LDL Receptor mRNAs in vivo
• Blockade of renin-angiotensin system downregulates tissue factor induced by monocyte-adhesion to endothelial cells via suppressing ICAM-1 and Ca^ signaling
• Inhibition of Rho and Rho-kinase downregulates the synthesis of tissue factor and plasminogen activator inhibitor-1 in cultured human monocytes
• Rho activation plays a role in hydrogen peroxide production induced by lysophosphatidylcholine
• Endothelial dysfunction accompanied with Rho activation in thrombin-stimulation and its prevention by statin in vivo in rats
• Rapid activation of Rho is involved in intracellular Ca^ mobilization via phospholipase C in lysophosphatidylcholine-stimulated endothelial cells
• L-NAME accelerates the synthesis of tissue factor and plasminogen activator inhibitor-i via MCP-1 in co-culture of endothelial cells and monocytes
• Monocyte-adhesion to endothelial cells impairs eNOS synthesis via activation of Rho and downregulation of extracellular signal-regulated kinase (ERK)

もっと見る 閉じる

スポンサーリンク