115 培養による再生靱帯様組織の力学的特性に及ぼす繰り返し負荷の効果

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Effects of cyclic load on the mechanical properties of ligament-like tissue constructed in vitro were studied. Fibroblasts obtained from the rabbit anterior cruciate ligaments were seeded within collagen gel which was combined with biodegradable polymer mesh. The fibroblast-collagen gel-mesh complexes were cultured for 7,14,and 21 days under non-loaded or cyclic loaded conditions (non-loaded and loaded groups, respectively) and, then, tensile tests of thus reconstructed ligament-like tissues were performed. Cross-sectional area of the complexes decreased with culture period in both groups, and the maximum load of the tissues markedly decreased by 14 days, The maximum load at 21 days was almost the same as that at 14 days in the non-loaded group; however, that in the loaded group was larger at 21 days than at 14 days. These results indicate that cyclic load may improve the mechanical properties of the reconstructed ligament-like tissues.
一般社団法人日本機械学会の論文