高血圧によるラット動脈壁組織の変化とこれに及ぼす加齢の影響(S02-2 生体組織のマルチスコープメカニクス(2).微細構造とメカニクス,S02 生体組織のマルチスコープメカニクス)

概要

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Effects of DOCA hypertension on histology were studied in the rat carotid artery. Arterial segments were sliced-into thin ring specimens, and each structural component (collagen, elastin, nuclei of smooth muscle cells) was stained. The fraction and radial distribution in 4 layers of each component were analyzed with an image analzer. Hypertension uniformly increased wall thickness in all layers. However, it affected the distribution of components; for example, the area fraction of extracelluer matrix (collagen+elastin) increased in the inner most layer where stress increase developed by hypertension is larger than in the other layers. Althought the total number of smooth muscle cells in the media did not change, each cell was hypertrophied. There were almost no differences in these results between growing rats and mature rats.
社団法人日本機械学会の論文
2004-09-04