FMLPおよびPHAが細胞膜の動態と細胞質の流動性に与える影響

概要

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The relationship between cell membrane metabolism (O^-_2 generation) and intracellular fluidity induced by FMLP and PHA was analysed by fluorescence polarization. The results were 1) The production of O^-_2 from neutrophils and intracellular fluidity were increased by stimulation with FMLP. PHA also enhanced the increase of intracellular fluidity of neutrophils. 2) The generation of O^-_2 from eosinophils was increased by stimulation with FMLP. However the intracellular fluidity was not increased. The response of eosinophils to PHA stimulation was indicated to be similar to those of neutrophils. 3) The neither generation of O^-_2 from lymphocytes nor intracellular fluidity were observed on stimulation with FMLP. The production of O^-_2 from lymphocytes was not induced by PHA. However intracellular fluidity was increased by PHA stimulation. 4) The fluorescence polarization value of resting neutrophils and eosinophils was found to be higher than that of resting lymphocytes.
日本アレルギー学会の論文
1985-02-28