イヌ冠動脈の流動抵抗に対する周辺脂肪層と心筋組織の力学的影響

概要

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The effect of mechanical properties and deformation of surrounding tissues on vascular resistance was investigated experimentally and theoretically for canine coronary arteries. In the experiment the hydraulic resistance was measured in epicardial coronary artery segments for two transmural pressures and four stretching conditions, i.e. 0% stretch, and 10% parallel, transverse, and biaxial stretch with respect to the vessel axis. The experimental results showed that the stretch in the direction of the vessel axis increased the resistance significantly for low transmural pressure. Finite element analyses were also performed. In the models the vessel was surrounded by a lipid layer and myocardial tissue. The simulation results showed that the existence of a lipid layer reduced both the resistance and the resistance change due to deformation of the myocardium. It was also shown that the resistance change due to myocardial deformation was smaller in the vessel near the surface compared to at the center of the myocardium.
一般社団法人日本機械学会の論文
1996-12-25