520 血管内皮細胞の基質伸展下での変形に対するばね系モデルを用いた数値シミュレーション(T10-1 マイクロ・ナノバイオテクノロジー(1):細胞の応答とその応用,大会テーマセッション,21世紀地球環境革命の機械工学:人・マイクロナノ・エネルギー・環境)

概要

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We formulated a mass-spring system model of the apical membrane of the cell to describe the deformation of a vascular endothelial cell under substrate stretching. The motion of each mass was governed by the equation of motion with an artificial damping effect, and the force was derived from the energy which was formulated by Wada and Kobayashi (2003) for a red cell. The energy was the sum of an elastic energy of springs in tension/compression, that of triangular elements in bending, constraints of the cellular volume and surface area. The cellular geometry was constructed from a set of images obtained by confocal scanning laser microscopy. The numerical simulation was performed under the condition of pure uniaxial stretching of a substrate by 10%, and was compared with results from a finite element analysis of a hyperelastic whole cell model. A comparison suggested a necessity of an evaluation of cytoskeletons.
社団法人日本機械学会の論文
2008-08-02