Four Cases of Thorotrast Injury and Estimation of Absorbed Tissue Dose in Critical Organs

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Four autopsy cases of thorotrast injury were presented, in which one case of liver cirrhosis and three cases of malignant tumors were included. The malignant tumors were diagnosed as cholangiocarcinoma, hemangioendothelioma and osteosarcoma, respectively. The dose delivered to critical organs, liver and the spleen, were measured spectrometrically and calculated using the method developed by Rundo, on the autopsy specimens. Several correction factors were introduced to obtain the final estimation of the dose. They are related to the equilibrium state of the thorotrast samples used, biological half life of ^<228>Ra, distribution of thorotrast granules in the tissue and reduction of the critical organ weight, etc. . Average tissue doses delivered were estimated as 0.58 to 2.6 rad per week for the liver and 0.92 to 5.6 rad for the spleen. Possible relationship between corrected tissue dose and pathological findings was discussed.
日本放射線影響学会の論文