Energy Dependency of RBE of Neutrons in the Range 0.43 to 14.1 Mev Effect on DNA Synthesis on Cellular Level

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The relative biological effectiveness of neutron radiation of 0.43, 0.65, 1.0, 1.5, 1.8 and 14.1 Mev was studied, taking the dosis for halving the labeling index of ^3H-thymidine as an index. Adult female mice of ddN strain and Carworth Farms BNL Stoner strain were exposed to single whole-body radiation of 250 kvp X-ray, 60Co gamma-ray and neutron radiation. 1) The RBE of total bone marrow cell and red cell precursor for 0.43 Mev neutron is highest, 4.1 and 3.6 respectively, with decreasing RBE for lowering LET. The RBE of total bone marrow cell is 1.2 for 14.1 Mev fast neutron. It is considered that there exists maximum RBE of neutron in the low energy range of less than 2 Mev. 2) The RBE of 14.1 Mev fast neutron are 1.1 and 1.2 for thymus and spleen, respectively. 3) The RBE of 14.1 Mev fast neutron is 1.8 for the intestine. The higher RBE of the intestine suggest higher radiosensitivity of this organ than others.