Overexpression of Heparin-Binding Growth-Associated Molecule in Malignant Glioma Cells
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概要
- 論文の詳細を見る
The highly invasive and angiogenic characteristics of malignant gliomas depend on the production of growth factors and angiogenic factors. Heparin-binding growth-associated molecule (HB-GAM) is a secreted growth factor that is mitogenic for endothelial cells. To examine the expression profile of HB-GAM in malignant glioma cells, messenger ribonucleic acid (mRNA) expression was analyzed in 10 malignant glioma cell lines, two glioblastoma tissue specimens, and two normal brain tissue specimens by the reverse transcription-polymerase chain reaction. HB-GAM mRNA was expressed in all specimens including normal brain tissue specimens. Western blot analysis revealed that HB-GAM protein contents in glioma cell lines and glioblastoma tissues were 1.8 to 6.3 times higher than those in normal brain tissues. The effect of neutralizing anti-platelet-derived growth factor (PDGF) antibody was also examined on the production of HB-GAM in malignant glioma cells, since malignant glioma cells secrete PDGF that upregulates HB-GAM expression. Treatment of U251 and T98G glioblastoma cells with the anti-PDGF antibody did not affect the HB-GAM production. These results suggest that HB-GAM is overexpressed in malignant glioma cells and is involved in tumor growth.
- 日本脳神経外科学会の論文
- 2004-12-15
著者
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Zhang Lei
Department Of Pharmacognosy School Of Pharmacy Second Military Medical University
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NAGANUMA Hirofumi
Department of Neurosurgery, University of Yamanashi, Faculty of Medicine
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SATOH Eiji
Department of Neurosurgery, University of Yamanashi Faculty of Medicine
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NUKUI Hideaki
Department of Neurosurgery, University of Yamanashi Faculty of Medicine
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Zhang Lei
Departments Of Neurosurgery And Biochemistry University Of Yamanashi Faculty Of Medicine
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Satoh Eiji
Department Of Cardiology Sendai City Hospital
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MABUCHI TADASHI
Department of Biochemistry, Interdisciplinary Graduate School of Medicine and Engineering, Universit
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Naganuma H
Department Of Neurosurgery University Of Yamanashi Faculty Of Medicine
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Naganuma Hirofumi
山梨大学 医学部脳神経外科学
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Naganuma Hirofumi
Department Of Neurosurgery National Hospital Organization Kofu Hospital
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Nukui H
Department Of Neurosurgery University Of Yamanashi Faculty Of Medicine
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Nukui Hideaki
Department Of Neurosurgery And Radiology Yamanashi Medical University And Department Of Radiology To
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Saya Hideyuki
Department Of Neuro-oncology The University Of Texas M.d.anderson Cancer Center
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MAEDA Shuichiro
Departments of Neurosurgery and Biochemistry University of Yamanashi, Faculty of Medicine
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Naganuma H
Department Of Neurosurgery Yamanashi Medical University
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Mabuchi Tadashi
Department Of Biochemistry Interdisciplinary Graduate School Of Medicine And Engineering University
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Mabuchi Tadashi
Departments Of Neurosurgery And Biochemistry University Of Yamanashi Faculty Of Medicine
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Nukui Hideaki
Department Of Neurosurgery University Of Yamanashi Faculty Of Medicine
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Maeda Shuichiro
Department Of Biochemistry Kumamoto University School Of Medicine
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Maeda Shuichiro
Departments Of Neurosurgery And Biochemistry University Of Yamanashi Faculty Of Medicine
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Zhang Lei
Department Of Biopharmaceutical Sciences College Of Pharmacy Harbin Medical University
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Zhang Lei
Department Of Biological Resource Sciences Faculty Of Agriculture Miyazaki University
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Ducati Alessandro
Ordinario Di Neurochirurgia Universita' Di Torino
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Laws Edward
Department Of Neurology And The Neurosurgical Visualization Laboratory And Department Of Neurosurger
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MUT Melike
Department of Neurosurgery University of Virginia
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SHAFFREY Mark
Department of Neurosurgery University of Virginia
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Naganuma Hirofumi
Department of Neurosurgery, University of Yamanashi Faculty of Medicine
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