Increase in the Capability of Interleukin 2 Gene-Transduced Renal Cell Carcinoma Cells to Induce Cytotoxic Lymphocytes.

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概要

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• The immunogenicity of human cancer cells transfected with Interleukin 2 (IL-2) gene, a potent vaccine candidate, has not yet been fully investigated. Human renal cell carcinoma (RCC) cells transduced with human IL-2 gene (RCC-IL-2) were investigated in vitro for the capability to induce lymphokine-activated killer (LAK) or cytotoxic T lymphocyte (CTL) activity in peripheral blood mononuclear cells (PBMC) or tumor-infiltrating lymphocyte (TIL). The RCC-IL-2 cells stimulated PBMC to demonstrate LAK activity, and also stimulated autologous TILs to proliferate and exhibit cytotoxicity relatively restricted to autologous tumor cells. In contrast, both parental RCC and RCC transduced with neomycin gene alone failed to induce these activities. These results indicate that RCC-IL-2 cells are more potent than the other RCC cells with regard to inducing cytotoxic lymphocytes against autologous tumor cells.

• 久留米大学医学部 The Kurume Medical Journal 編集部の論文

著者

• Itoh Kyogo

  Department Of Immunology

• NAKAO Masanobu

  Department of Immunology, Kurume University School of Medicine

• SAKATA Motoko

  Department of Immunology, Kurume University School of Medicine

• Nakao Masanobu

  Department Of Immunology

• MATSUI Hiroshi

  Ajinomoto Institute of Life Sciences

• Miyajima Jiro

  Department Of Urology Kurume University School Of Medicine

• Saya Hideyuki

  Department Of Neuro-oncology The University Of Texas M.d.anderson Cancer Center

• Morita Tatsuo

  Department Of Applied Physics Waseda University

• Masuoka Kazuhiro

  Department Of Hematology Toranomon Hospital

• MORITA TATSUO

  Departments of Immunology, The University of Texas, M. D. Anderson Cancer Center

• UMEZU YASUIKI

  Departments of Immunology, The University of Texas, M. D. Anderson Cancer Center

• SEITO DAI

  Departments of Immunology, The University of Texas, M. D. Anderson Cancer Center

• AUGUSTUS LAZEL

  Departments of Immunology, The University of Texas, M. D. Anderson Cancer Center

• ITOH KYOGO

  Departments of Immunology, The University of Texas, M. D. Anderson Cancer Center

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