Development of a New Diagnostic Tool for Pancreatic Cancer: Simultaneous Measurement of Antibodies against Peptides Recognized by Cytotoxic T Lymphocytes
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概要
- 論文の詳細を見る
One of the longstanding challenges in the treatment of pancreatic cancer, the fifth most common cancer worldwide, is to establish a simple and reliable diagnostic marker for the disease. This study examined whether or not the simultaneous measurement of plasma levels of IgG antibodies (IgGs) reactive to peptides recognized by cytotoxic T lymphocytes was useful for screening of pancreatic cancer. Sixty-three kinds of peptides were tested for their reactivity to plasma IgGs of pancreatic cancer patients with Luminex system followed by discriminatory analysis of the results using the Statistical Discovery Software. Under these circumstances, 83% of subjects with pancreatic cancer and 12% of healthy donors were diagnosed as having pancreatic cancer, respectively. These results suggest that the simultaneous measurement of IgGs reactive to these peptides could potentially be useful as a new diagnostic tool to screen for pancreatic cancer.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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SHICHIJO Shigeki
Department of Immunology, Kurume University School of Medicine
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Itoh Kyogo
Department Of Immunology
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Komatsu Nobukazu
Department Of Immunology And Immunotherapy Kurume University School Of Medicine
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Shichijo Shigeki
Department Of Immunology And Immunotherapy Kurume University School Of Medicine
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Yanagimoto Yasuaki
Department Of Surgery Kansai Medical University Hirakata Hospital
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Tanaka Masahiro
Department Fixed Prosthodontics And Occlusion Osaka Dental University
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OKUDA SEIYA
Department of Medicine, Kurume University School of Medicine
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OKA MASAO
Department of Surgery, Yamaguchi University School of Medicine
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YANAGIMOTO YASUAKI
Department of Surgery, Kansai Medical School
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