The Effects of Allyl Chloride on Ca^<2+>, Ca^<2+> -Free CaM, cAMP and Ca^<2+> / CaM-PK II Activity in Nerve Cells

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概要

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• The Effects of Allyl Chloride on Ca^<2+>, Ca^<2+>-Free CaM, cAMP and Ca^<2+>/CaM-PK II Activity in Nerve cells : Keqin X_<IE>, et al. Instite of Toxicology, Shandong Medical University-Nerve cells in a culture from chicken embryo brain were used to study the allyl chloride-induced effects on the contents of intracellular Ca^<2+>, Ca^<2+>-free CaM, cAMP and the sctvity of Ca^<2+>/CaM-PK II. The results showed that with the increase in the concentration of allyl chloride there was a significant increase in the content of Ca^<2+> and cAMP, and the activitiy of Ca^<2+>/CaM-PK II in the cells (P<0.01), but a marked decrease in Ca^<2+>-free CaM (P<0.01). The results suggest that the neurotoxicity of allyl cholride might be related to the increase in intracellular Ca^<2+> and the activation of CaM and Ca^<2+>/CaM-PK II, eventually leading to the accumulation of degenerative MT in the nerve axon.

• 社団法人日本産業衛生学会の論文

著者

• ZHANG Min

  Institute of Microbiology and Epidemiology

• Zhang Lei

  Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University

• Sun Keren

  Institue Of Toxicology Shandong Medical University

• Zhang Lei

  Institue Of Toxicology Shandong Medical University

• XIE Keqin

  Institue of Toxicology, Shandong Medical University

• GAO Shunjyun

  Institue of Toxicology, Shandong Medical University

• Xie Keqin

  Institue Of Toxicology Shandong Medical University

• Gao Shunjyun

  Institue Of Toxicology Shandong Medical University

• Zhang Lei

  Department Of Biological Resource Sciences Faculty Of Agriculture Miyazaki University

• Zhang Lei

  Department Of Mechanical Engineering The University Of Tokyo

• Zhang Min

  Institue Of Toxicology Shandong Medical University

• Gao Shujun

  Institue of Toxicology, Shandong Medical University

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