Disturbed Spatial Learning of Rats After Intraventricular Administration of Transforming Growth Factor-β1
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概要
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Patients with subarachnoid hemorrhage (SAH) who later suffer hydrocephalus show persistently high levels of transforming growth factor-β1 (TGF-β1) in the cerebrospinal fluid after the onset of SAH. Recombinant TGF-β1 induces hydrocephalus in mice. This study examined the spatial learning ability of rats after intraventricular administration of TGF-β1. Thirteen-week-old Wistar rats were treated with 0.8 or 8.0μg of human recombinant TGF-β1 by direct injection or via osmotic pump. Three months later, their spatial learning ability was evaluated with a Morris water maze. Ventricular size, ultrastructural features, and sodium-potassium-adenosine triphosphatase (Na^+,K^+-ATPase) activity of the subarachnoid space were examined. All three TGF-β1-treated groups clearly exhibited impaired spatial learning ability, but they did not exhibit ventricular dilation. Histological examination revealed subarachnoid fibrosis and deactivation of Na^+,K^+-ATPase in the arachnoid cells. These findings are similar to those of our previous experiments involving injection of TGF-β1 in mice. The present and previous studies suggest that subarachnoid fibrosis is an important factor in the disturbance of the spatial learning ability of rats, whereas ventricular size is less important.
- 日本脳神経外科学会の論文
- 2002-04-15
著者
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HONGO Kazuhiro
Department of Neurosurgery, Shinshu University School of Medicine
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Murakami Kentaro
Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University
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Hongo Kazuhiro
Department Of Mechanical Engineering School Of Systems Engineering National Defense Academy
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Tada Tsuyoshi
Department Of Neurosurgery Shinshu University School Of Medicine
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TANAKA Yuichiro
Department of Neurosurgery, Shinshu University School of Medicine
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Tanaka Yuichiro
Department Of Neurosurgery Shinshu University School Of Medicine
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NAKAZATO Fumi
Department of Neurosurgery, Shinshu University School of Medicine
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SEKIGUCHI Yasuyuki
Department of Neurosurgery, Shinshu University School of Medicine
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YANAGISAWA Shin
Department of Neurosurgery, Shinshu University School of Medicine
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Pitts Lawrence
Department Of Neurosurgery Moffitt Hospital University Of California
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Murakami Kentaro
Department Of Neurosurgery Shinshu University School Of Medicine
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Tanaka Yuichiro
Department Of Materials Technology Faculty Of Engineering Chiba University
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Nakazato Fumi
Department Of Neurosurgery Shinshu University School Of Medicine
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Yanagisawa Shin
Department Of Neurosurgery Shinshu University School Of Medicine
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Sekiguchi Yasuyuki
Department Of Neurosurgery Shinshu University School Of Medicine
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Murakami Kentaro
Department Of Clinical Cell Biology Chiba University Graduate School Of Medicine
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Shimizu Hiroyuki
Department Of Biochemistry And Molecular Biology Center For Advanced Medical Technology Nippon Medic
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TANAKA Yuichiro
Department of Bioresource Science, Ibaraki University
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