ヘモグロビンの脳血管収縮能に関する研究(第2報) : Ca^<++>-blocker および各種拮抗物質の抑制効果について

概要

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In vitro experiments were carried out to determine the inhibitory effects of several agents, especially a Ca^<++>-blocker, nifedipine, on hemoglobin-induced contractions of dog basilar arteries. Agents tested included methysergide, phentolamine, mepyramine, and aspirin. None of these agents significantly inhibited hemoglobin-induced contractions. This indicates that serotonin, norepinephrine, histamine, and prostaglandins are not involved in the contractile activity of hemoglobin. The inhibitory effect of cclic AMP on hemoglobin-induced contractions was slight even at high concentrations. In Ca^<++>-free solution, basilar arteries showed no response to hemoglobin. Nifedipine was found to be a highly potent inhibitor of hemoglobin-induced contractions. The inhibitory effect of nifedipine on hemoglobin-induced contractions was greater than that of papaverine. These data suggest that nifedipine might be useful in the treatment of vasospasms following rupture of an aneurysm.
日本脳神経外科学会の論文
1980-08-15