多発性転移を示した側頭骨原発のmalignant fibrous histiocytomaの1例

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Malignant fibrous histiocytoma (MFH) is well known as a soft tissue tumor of the extremities. MFH of the skull is relatively rare, especially with multiple metastases. A 59-year-old female was admitted with complaint of a painless tumor in the left temporal region in March, 1983. Skull plain film showed an osteolytic and osteosclerotic lesion, with a "moth-eaten" appearance, of the temporal bone. Computed tomography (CT) scans revealed a high density mass lesion invading intra-and extracranially. Selective external carotid angiography revealed abnormal tumor vessels like a corkscrew and a marked tumor stain. The tumor was extirpated. The histological diagnosis was MFH. The patient received chemotherapy with mitomycin C intraoperatively, and was discharged without any neurological deficits. She was readmitted with complaint of general fatigue 7 months later. Plain chest X-ray films showed a tumor in the mediastinum and depressed fracture of the third thoracic vertebra. CT scans revealed the invasion of the mediastinal tumor to the spinal canal and the hydrothorax. She died in July, 1984. The autopsy showed multiple metastases of MFH to the mediastinum, the third thoracic vertebra, and the right lung, and an associated meningioma in the left cerebellopontine angle. There was no local recurrence.
日本脳神経外科学会の論文
1987-08-15

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