ヌードマウス可移植性小児悪性固型腫瘍の放射線感受性の検討

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Studies were undertaken to evaluate the radiotherapeutic response of five human tumor lines serially transplanted in nude mice (BALB/c, nu/nu). They included a neuroblastoma (CH-NB-1), Wilms tumor (CH-W-4), hepatoblastoma (CH-HB-1), yolk sac tumor (CH-YS-l), and rhabdomyosarcoma (CH-RS-2). Their histological appearance and growth rates were stable, with volume doubling times ranging from 3.5 to 6.0 days. When the therapeutic response was measured by growth-delay method, there were wide differences in response to radiotherapy. Neuroblastomas and yolk sac tumors responded well; Wilms tumors and hepatoblastomas showed modest response; rhabdomyosarcomas responded poorly. The results were similar to those reported in the patients treated with the same agents. Studies of in-vivo cell survival were made in hepatoblastoma xenograft line (CH-HB-1). The survival curve showed an initial sensitive component, a Do of 1.1 Gy and a radioresistant component, a Do of 3.4 Gy. This suggests that there is hypoxic cell fraction which is radioresistant in this tumor.
日本小児外科学会の論文
1984-06-20

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