小児横紋筋肉腫の治療法の検討

概要

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Nineteen cases of childhood rhabdomyosarcoma was reviewed. Ten were male and nine were female. The age of the patients was from 6 months to 11 years, and 13, about two-thirds were under 3 years old. The sites of the primary lesion were various, and 11 were in the genitourinary system. The histologic type was embryonal 15, alveolar 3, and pleomorphic 1. Before 1975, there were 8 cases and only one was survived. It was sharply contrasted with 11 cases from 1975 to 1980, in which 8 are surviving without disease. The better result was obtained by multimodal therapy, especially introduction of effective chemotherapy namely VAC. It was shown by angiography that rhabdomyosarcoma is a vascular-rich tumor. So, recently we use intraarterial catheter to infuse chemotherapeutic agents. After intraarterial infusion of agents with radiation, the shrinkage of the tumor was remarkable and histological examination revealed nearly complete disappearance of tumor cells. With this method, it is possible that patients can be cured by more restricted operation, especially when the lesion is in the genitourinary system or in extremity.
1982-04-20