神経芽細胞腫の特性に関する研究 (第一報) : 年齢, 病気別にみた予後の検討

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The prognosis of neuroblastoma is said to be affected by factors such as age of onset, stage of the disease, histological type, site of origin and peripheral leucocyte count. In this survey, an analysis was carried out on the clinical data of 380 cases of neuroblastoma which was received from the 11 facilities in Japan. The results were compared with those Breslow and McCann performed on the 246 cases of CCSGA in 1971. The survival rate at each stage, patient's age and the frequency of outbreak were compared with those of CCSGA cases. The results was summarized as follows : (1) The survival rate under 1 year of age was lower in comparison to CCSGA, which was considered due to lager proportion of the patients of stage III and IV. (2) The survival rate and frequency of outbreak of stage IV-S group were lower in this survey than CCSGA cases. (3) In the stage I and II groups, the frequency of outbreak at the age over 2 years was greater in this survey. The estimated survival curve was also compared with that of CCSGA cases for each curve with the real figures. The results were as follows : (1) The estimated survival curve in two groups was far different. This suggests that there is a considerable difference from the real figures. (2) The estimated survival curve for each stage might be obtainable by shifting the standard sigmoid curve (the survival curve by the age of the disease) along the axis of ages. (3) A higher correlation seemed to be present between the stage and the age in neuroblastoma.
日本小児外科学会の論文

神経芽細胞腫の特性に関する研究 (第一報) : 年齢, 病気別にみた予後の検討

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