DI及び調剤業務への粉末X線回折法の応用 : 第2報 : 顆粒剤などの複合製剤及び錠剤(カプセル剤)の粉砕物を混合した散剤中の医薬品の同定

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In the hospital pharmacy, the analysis of the ingredients in a mixed powder and the codeless tablets or capsules is important pharmaceutical service, but the complete analysis is currently almost impossible because a drug in the mixture is mainly deduced from its characteristic odor or taste and/or color. In this article, the application of X-ray powder diffractometry to the analysis of the ingredients was studied. Each ingredient was identified by comparing the intensity and number of the diffraction peaks with those of the standard substances. The ingredients in the mixture were determined successively by subtracting the peaks of the identified ingredient from the whole peaks of the mixture. For the purpose of this diffractometric analysis, four data bases such as the powder of organic medicines, the granule of organic medicines and the pulverized tablet and capsule were newly constructed. Since these data bases identify the whole peaks pattern of the preparation containing many constituents as a pattern of a certain drug, each drug, even in the complicated mixed powder containing granules (and/or fine granules) and tablets (and/or capsules) pulverized, could be easily analyzed. However, in the complicated mixture containing fine granules or granules, the concentration of the ingredients was necessary to raise analytic precision for this diffractometry. Each ingredient in the mixture could be qualitatively determined by the combined use of these data bases and the rough sieving through No 30 and 80 screens. It proved that the ingredients of codeless tablets or capsules were identified by using these data bases. In conclusion, the results presented suggests that this X-ray powder diffractometry can be applied to the routine DI and dispensing services in hospital pharmacy.
日本医療薬学会の論文
1992-12-21

DI及び調剤業務への粉末X線回折法の応用 : 第2報 : 顆粒剤などの複合製剤及び錠剤(カプセル剤)の粉砕物を混合した散剤中の医薬品の同定

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