DI及び調剤業務への粉末X線回折法の応用 : 第1報 : 散剤中の混合成分の鑑別

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The discrimination of drugs is a very important pharmacist's role in the hospital pharmaceutical practice. At present, however, it is extremely difficult to analyze the ingredients of a mixed powder accurately, except the case that a drug in the mixed powder is deduced from its characteristic odor or taste and/or color, in the routine DI and dispensing Services. In this paper, the analysis of the ingredients in a mixed powder was studied by the use of X-ray powder diffraction. Ingredients in the mixed powder were identified by comparing the intensity and the number of observed diffraction peaks to the corresponding peaks of the standard substances and by subtracting successively the peaks of the identified ingredient from the whole peaks of the mixture. Three kinds of original data bases such as the powdered organic and inorganic drugs, the powder or fine granule of organic drugs were constructed in order to apply the X-ray powder diffractometry for identification of the drugs. In general, a thinner sample is preferred for X-ray powder diffractometry, However, the sample about O.5mm in thickness was found to be well suitable for the identification of the ingredients of the mixed powder. The ingredients of the mixture consisting of one to three kinds of organic drugs were completely identified. In the mixture of four kinds of organic drugs, three ingredients could be identified, but the residual ingredient was not always identified depending on the mixing ratio. Each ingredient of the inorganic mixture was analyzed in a similar manner as that for the organic mixture. The time required for measurement was 30min, and the time for analysis was about 30sec, so this X-ray powder diffractometry is very useful and applicable to the routine DI and dispensing services in a hospital pharmacy.
日本医療薬学会の論文
1992-06-20

DI及び調剤業務への粉末X線回折法の応用 : 第1報 : 散剤中の混合成分の鑑別

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