自動分割分包機による散剤・顆粒剤混合物の分割後の均一性の検討

概要

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Components of a powder-granule mixture are liable to be separated by vibration. For this reason, in order to evaluate a practicability of the machine (L-2) equipped with a linear vibrating feeder, comparative examinations were made on the uniformity of the mixtures after the division by each of 3 machines (L-2, B and R). The machines used were the same as that which had been used in the previous work. The samples used were the powder-granule mixtures in 8 grades of mixture ratio (Powder/granule) ranging from 1/15 to 15/1, and powder and granule were prepared in our pharmacy. 10g of the sample was divided into 15 Parts by each of these machines, and dividing was repeated 5 times. As for variation of percent powder content after the division, the difference between the machine L-2 and B was not significant. However, as for mixture weight and powder weight after division, the machine L-2 showed smaller variations than the machine B. When the machine L-2 is used, the mixture shows a separation tendency because of vibration, which is one of two main functions of the feeder. However, each of the components is considered to be divided accurately by alternating motion, which is the other function of the feeder. The machine R caused larger variations of mixture weight, powder weight and percent powder content after the division than any other machine tested.
日本医療薬学会の論文
1982-08-20