腎移植患者におけるシクロスポリン血液内分布を支配する生理的要因に及ぼすプレドニゾロンの影響

概要

論文の詳細を見る
The effects of prednisolone (PSL) on physiological factors, i. e. plasma lipids and blood proteins regulating cyclosporin A (CsA) blood distribution were evaluated in renal transplant patients. The clinical data of 46 blood samples from 10 outpatients with a stable renal function, who received CsA and low dose PSL (10mg/day), were thus analyzed. The PSL concentration in plasma (C_PSL) showed a significant positive correlation with hematocrit (HCT) and total cholesterol (CHO) but not with any other clinical laboratory tests related to either protein or lipid metabolism. In a multiple regression analysis the contribution that selected variables made to the CsA trough level was as follows : CHO>HCT>dose of CsA>C_PSL.This finding suggests that the drug-interaction between PSL and CsA was much due more to either the changes in the physiological factors regulating the CsA blood distribution via protein anabolism or the unusual lipid metabolism of PSL than dut to the enzyme-inducing action of PSL for CsA. Taking the PSL concentration in plasma and the effects of PSL on protein or lipid metabolism into consideration, it is thus possible to optimize the effect of immunosuppressive therapy in renal transplant patients.
日本医療薬学会の論文
1997-08-10