ニューロパシックペイン神経炎モデルに対するクロニジンの影響(第471回大阪歯科学会例会)

概要

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We examined the effect of clonidine with CFA (complete Freund's adjuvant) on neuritis in Sprague-Dawley rats us-ing behaviorassays. The animals were anesthetized and the common sciatic nerves were exposed bilaterally after in-traperitoneal injection of 50 μg / kg clonidine or saline. The left nerve was wrapped in a band of sterile hemostatic oxi-dized cellulose saturated with 50μL CFA. The right nerve was only exposed. Intraperitoneal injection of clonidine or saline were administered every 12 hours for a total of eight times. The response of the rats was checked 12 hours af-ter the last injection. We found that cold-allodynia and mechano-hyperalgesia, but not mechano-allodynia, were de-pressed in the rats that had received clonidine.
大阪歯科学会の論文
2000-06-25