アルコール摂取が血清脂質およびリポタンパクに及ぼす影響

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This study was designed to elucidate the effect of normal and excessive drinking on serum lipids and lipoproteins. Serum samples obtained from 46 healthy males (12 non-drinkers, 34 drinkers) and 13 male alcoholics were used for analysis of lipoprotein profiles as well as for lipids and apolipoproteins assay. Lipoprotein profile was obtained by HPLC method using gel-permeation column and subclasses of HDL peaks were analyzed by Gaussian method. Blood tests for alcoholics were performed successively 5 time at 1st, 2nd, 4th, 8th, and 12th, week after admission. No significant difference was found in serum lipids except Apo A II and Apo C III between non-drinkers and drinkers in healthy group and all lipoprotein profiles showed normal patterns with normal size HDL. In alcoholics, all patients showed abnormal lipoprotein profiles characterized by appearance of chylomicron and VLDL. Alcoholics with normal liver function showed higher HDL-C and those with impaired liver function, on the contrary, showed low HDL-C. Subclass analysis revealed that large size HDL increased regardless of liver function in alcoholics. Lipid and lipoprotein abnormality in alcoholics recovered rapidly after abstinence toward normal pattern. These results indicated that excessive intake of alcohol induced abnormal lipoprotein metabolism characterized by appearance of abnormal lipoprotein metabolism characterized by appearance of abnormal HDL with larger size than normal HDL.
実践女子大学の論文
2002-03-29

アルコール摂取が血清脂質およびリポタンパクに及ぼす影響

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