神経回路網の形成制御に関する研究(第1報) : 神経細胞培養のための細胞の初期分布密度について

概要

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This study focuses on the construction of an information processing and control system using an actual cell. The emphasis is placed on both the initial location of a cell and the cellular distribution density when a nerve cell is cultivated. On the basis of physiological knowledge, a calculation program was made which simulated the activity of a nerve cell. Then, the excitation transmission from a cell was observed in the simulation by randomly changing the initial cell location. The transmission performance of the excitation was evaluated by using the transmission ability function defined in this study. It is found from simulation results that a nerve circuit network forms a closed circuit when the distribution density of a cell becomes large, although it is a barrier in transmitting the excitation. Further, the cellular distribution density shows its optimal value when a cell condition is adequately arranged. As a result, there is the possibility of controlling the performance of a nerve circuit network by changing the initial cell location.
公益社団法人精密工学会の論文
1998-12-05