ラットにおけるカルベジロールとアムロジピンの用量依存的相互作用

概要

論文の詳細を見る
The pharmacokinetic interaction between carvedilol, a nonselective β -blocking agent and amlodipine besilate, a dihydropyridine calcium-channel blocker were investigated In rats. To determine the concentration-time profile of plasma carvedilol, blood samples were obtained from the tail vein after the oral administration of carvedilol either with or without amlodipine besilate. The plasma carvedilol concentrations and pharmacokinetic parameters, comprising the area under the concentration-time curve from 0 to 24 hours (AUC_<0-24> ) showed no changes after the simultaneous oral administration of 20 mg/kg carvedilol and 5 mg/kg amlodipine besilate. In contrast, the plasma carvedilol concentrations at 6 hr-12 hr and AUC_<0-24> after the oral administration of carvedilol with 40 mg/kg amlodipine besilate were significantly higher than those without amlodipine besilate. These results suggested the pllamlacokinetic interaction between carvedilol and amlodipine to be dependent on the dose of amlodipine.
1999-02-10