ラットにおけるフレロキサシン血中代謝動態に及ぼす塩酸タリペキソール投与の影響

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Drug interaction of fleroxacin, new qunolone antibiotics, and talipexole, an antiparkinsonian drug, was studied in rats. When talipexole was administered orally before the oral administrations of fleroxacin, the plasma concentrations of fleroxacin and its metabolite, fleroxacin N-oxide, decreased. The maximum plasma concentrations (C_< max>) of fleroxacin and fleroxacin N-oxide decreased and the time needed to reach C_<max> (T_<max>) was also delayed significantly (p<0.05) as compared to the control. This finding suggests that the pretreatment with talipexole thus decreases the rate of absorption of fleroxacin from the gastro-intestinal tract In rats. On the other hand, when fleroxacin and talipexole were administered simultaneously, the plasma concentrations of fleroxacin and fleroxacin N-oxide increased. Regarding the absorption rate constant, the C_<max> and area under the plasma concentration-time curve from O to 24 hours (AUC_< 0-24>) of fleroxacin increased whereas T_< max> decreased significantly (p<0.05), compared to the control. Both the elimination rate constant and the C_<max> of fleoxacin N-oxide also increased whereas the T_<max> decreased significantly (p<0.05). The findings suggest that the simultaneous administration of talipexole increases the absorption rate of fleroxacin and may decrease the metabolism of fleroxacin to fleroxacin N-oxide. In conclusion, the results of the present study suggest that talipexole interacts with fleroxacin in a different way than when it is administered before and/or simultaneously with the oral administration of feroxacin.
1998-02-10

ラットにおけるフレロキサシン血中代謝動態に及ぼす塩酸タリペキソール投与の影響

スポンサーリンク

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スポンサーリンク