ラット血漿中カルベジロール動態におけるジヒドロピリジン系Ca拮抗剤の影響

概要

論文の詳細を見る
The purpose of the present study was to evaluate the pharmacokinetic interaction in rats between cilrvedilol and three kinds of dihydropyridine calcium-channel blockers. including ni-cilldipine hydrochloride, nifedipine and felodipine by high-performance inquid chromatography using a solid phase extraction column. The plasma crvedilol concentrations were found to be significantly higher than the control levels at 30 min-24 hr and 3-8 hr after the simultaneous administration of 20 mg/kg carvedilol and 40 mg/kg nicaldipine hydrochloride and 40 mg/kg nifeciipine. respectively. In addition. the drug pharmacokinetic parameters, comprising the area under the concentration-time curve up to 24 hours (AUC_<0-24>), were 6.7 and 3.0 times higher after the administration of both carvedilol and nicaldipine hydrochloride and nifedipine, respectively. In contrast, after the administration of carvedilol and 5 mg/kg felodipine. the AUC_<0-24> showed no change. These changes are though to be attributable to either the vasodilator-induced changes in the hepatic first-pass metabolism or the metabolic inhibition.
日本医療薬学会の論文
1999-02-10