ポビドンヨードシュガー配合塩化リゾチーム軟膏の安定性

概要

論文の詳細を見る
Compatibility of lysozyme chloride ointment (Reflap^[○!R] ointment, LO) was studied using two kinds of povidone-iodine sugar ointments. One was povidone-iodine sugar ointment (PSG), which was prepared in the hospital pharmacy, and the other was U-pasta KOWA ointment (UPK) which is available on the commercial market. In this study, LO was mixed with PSG or UPK in a 3:1 ratio by weight. Lysozyme (LZ) activity and the residual percentage of available iodine were determined in the mixtures over a 28-day period, and the change in LZ was also investigated using SDS-polyacrylamide gel electrophoresis. No changes were observed in LZ activity and LZ molecular weight in the mixtures, while the available iodine dramatically decreased with time in a dark location at room temperature. On the other hand, in a dark place at 5℃, the residual percentages of available iodine were maintained above 90% in PSG-LO stored for 14 days after mixing and in UPK-LO stored for 28 days after mixing. From the above results, it was concluded that PSG-LO remained compatible up to 14 days, and UPK-LO for at least 28 days at 5℃.
日本医療薬学会の論文
1993-12-20