大食症(Bulimia)の視床下部-下垂体-甲状腺系について

概要

論文の詳細を見る
In order to investigate the function of the hypothalamo-pituitary-thyroid axis in patients with bulimia of normal weight. basal levels of serum T_3,T_4,rT_3,Free T_3,Free T_4 and TSH, as well as the responses of TSH and T_3 to TRH were studied. The subjects were 14 normal weight women who satisfied criteria for the diagnosis of bulimia according to the DSM-III. None had a history of weight loss suffcient to qualify for the diagnosis of anorexia nervosa. The results were compared to those found in a group of 8 normal subjects. The mean basal T_3 and T_4 levels in patients (71.1±4.0 ng/dl, M±SE, 6.3±0.4 μg/dl) were significantly lower than those of control subjects. Serum Free T_3 and Free T_4 of the patients were also lower than in controls whereas the mean basal rT_3 concentration of the patients was not Signiacantly diHerent from those of controls. With the patient group, TSH responses to TRH were normal in 7 cases, delayed in 5 and low in 2,maximun increase in serum T_3 (Max ⊿T_3), Max ⊿T_3/MAX ⊿TSH and net secretory response appeared significantly lower as compared with normal subjects, while the increment % was lower but not significantly. These results suggest that patients with bulimia of normal weight have abnormalities in the hypothalamo-pituitary-thyroid axis.
日本心身医学会の論文
1986-10-01