過換気症候群とβ受容体機能 : 過換気症候群に対するβ遮断剤の臨床効果(呼吸器心身症の病態と治療(第21回日本心身医学会総会シンポジウム))

概要

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In the previous report, we clarified that the increase of sensitivity of the β receptor played a very important role in the pathogenesis of HVS. In the present study, preventive effect of the hyperventilation attack by β blocker administration was studied for a long period.In 38 cases were administered daily dose of 10 or 15mg of bufetolol hydrochloride only and in 29 cases associated with intense anxiety were administered same amount of bufetolol hydrochloride in combination with anti-anxiety drugs for several months.The following results were obtained.(1) The frequency of HV attacks decreased significantly under each therapeutic method. The frequency, however, decreased more significantly in the group where the use of anti-anxiety drugs was combined.(2) The grade of HV attacks significantly decreased under each therapeutic method. The grade of HV attacks, however, decreased more significantly in the group where the use of anti-anxiety drugs was combined.(3) From the above results, it was found necessary to suppress not only the sensitivity of the β receptor (physical factor) by β blocker, but also the anxiety (emotional factor) by anti-anxiety drugs in the long term management of HVS.
日本心身医学会の論文
1980-10-01