過換気症候群の症候発言へのβ受容体の役割

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153 patients with the diagnosis of hyperventilation syndrome (HVS) were treated by us for the past five years and nine months. A study was carried out to investigate the role of β-receptor in the pathogenesis of HVS. The following results were obtained. (1) 15 mg of bufetolol hydrochloride known as β-blocker was administered to 24 cases who showed typical clinical manifestations by HV test, and 75 minutes after administration, HV test was performed again to evaluate clinical manifestations. The clinical manifestations of HVS were strikingly suppressed after administration of the βblocker. (2) At the same time, the change of arterial-blood PaCO_2 and pH induced by HV test was examined in 5 cases with typical HVS before and 75 minutes after administration of the βblocker. The decrease of PaC0_2 and increase of pH by HV test was confirmed in each HV test and the degree of change was almost equal in each HV test. (3) l.5 mg of hexoprenaline sulfate known as β-stimulant was administered to 13 cases who were diagnosed as HVS from past history without typical clinical manifestations of HVS by HV test. 70 minutes after administration of hexoprenaline sulfate, HV test was performed again. The clinical manifestations of HVS were surprisingly aggravated by HV test after administration of hexoprenaline sulfate. (4) On the basis of above results, it was concluded that the clinical manifestations of HVS were caused not solely by the change of arterial PaCO_2 and pH, but by the presence of the hyperfunction of the β-receptor. (5) The level of catecholamines was measured in 4 typical cases and 3 normal subjects before and after HV test to clarify whether the hyperfunction of β-receptor during HV attack was due to the hypersecretion of adrenaline or due to the increase of sensitivity of the β-receptor itself. No significant difference about adrenaline level was discovered between two groups. (6) From the above detailed information, it was concluded that the increase of sensitivity of the β-receptor was a very important factor for the pathogenesis of HVS.
日本心身医学会の論文
1979-08-01

過換気症候群の症候発言へのβ受容体の役割

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