視床下部Serotoninの情動と内分泌に及ぼす影響について(心身症における情動と内分泌2第15回日本精神身体医学会総会シンポジウム)

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The clinical and experimental studies on the role of brain amines in the integration of behavioral and pituitary-adrenocortical functions under emotion revealed following results.Immobilization resulted in the decrease in brain noradrenaline and the increase in plasma corticosterone in rats, and the repetition of immobilization caused the diminished responses in both noradrenaline and corticosterone levels.Non-learner, which was supposed to be exposed to chronic psychic stress, in conditioned avoidance elavorated in rats showed the significant increase in hypothalamic noradrenaline.The depletion of brain noradrenaline in olfactory bulb-lesioned rats following intraventricular administration of 6-hydroxydopamine, a specific depletor of catecholamine which did not cross blood brain barrier, resulted in the suppression of rearing and the facilitation of defenseaggressiveness.These results seemed to demonstrate the importance of brain noradrenaline in the regulation of behavioral responses under emotion.There was, however, no evidence to suggest the control of pituitary-adrenocortical function by brain noradrenaline in any aspect of resting level, feed-back mechanism or of the response to stressors.Thus there may be little possibility that brain noradrenaline plays some role in the integration of behavioral and pituitary-adrenocortical responses under emotion.FK-880 (Sulpiride), a new psychoactive drug which was proved to block muricide reaction and to decrease the serotonin turnover in rats (Valzelli & Bernasconi : 1972), showed a tranquilizing effect in double blind trial utilizing diazepam as an active placebo.The administration of the agent caused also galactorrhea in some female cases, reversible impairment in metopyron test and normal response in ACTH test and in TRH test with normal initial level of TSH. These results suggested the supporession in hypothalamus.The administration of 5-hydroxytryptophan, the precursor of serotonin, stimulated adrenocortical function in three out of eight healthy volunteers.This stimulative effect of 5-hydroxytryptophan was verified in rat experiments which showed that the administration of the chemical caused the increase in both brain serotonin and the levels of corticosterone in plasma and adrenal glands. The positive dose response in brain serotonin and corticosterone levels after 5-hydroxytryptophan was also observed. The correlation coefficient between brain serotonin and plasma corticosterone was+0.78 with the value of tanθ of 0.0036.Based on these results the role of brain serotonin in the integration of behavioral and pituitary-adrenocortical functions under emotion was briefly discussed.
日本心身医学会の論文
1975-02-01

視床下部Serotoninの情動と内分泌に及ぼす影響について(心身症における情動と内分泌2第15回日本精神身体医学会総会シンポジウム)

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