アロキサン糖尿病に及ぼす条件情動ストレスの影響

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The purpose of this study was to observe the influences of stressfull life-situation on diabetes mellitus. The experimental animals were Wistar male rats. After confirming the appearance of glycosuria in the rats treated with the intraabdominal administration of alloxan (150 mg/kg), the conditioned emotional stress (CES) by the method of Ader-Friedman was induced, and the levels of blood sugar, immunoreactive insulin (IRI), non-esterified fatty acid (NEFA) and of adrenal catecholamines were measured. The results obtained were as follows ; 1) The effects of exposure to a session of 12 hours'CES were examined in non-treated rats and in alloxantreated diabetic rats. In alloxan-diabetic rats, the contents of adrenal catecholamines, especially of adrenalin decreased markedly, while the levels of NEFA and blood sugar increased, and IRI value decreased remarkably. 2) The effects of one, two and twenty sessions of 12 hours'CES on adrenal catecholamines in the case of alloxan-induced diabetes in the rats were studied when the persistent hyperglycemia developed. In the group of diabetic rats exposed to CES, the contents of catecholamines decreased as compared with those of nontreated diabetic rats. But, when the session of 12 hours' CES was repeated twenty times, this decrease of catecholamines returned to the control level. 3) The observations of the same categories were done as regards blood sugar, IRI and NEFA. The levels of blood sugar showed the tendency to decrease regardless of the repetition of 12 hours'CES. Serum IRI increased after one session of CES, but there was not found difference of IRI value between non-treated rats and ones treated with twenty courses of 12 hours'CES. The levels of NEFA showed the tendency to decrease in the cases of rats treated with one and with twenty sessions of CES. In a selected group of alloxan-diabetic rats showing the blood sugar level over 200 mg/dl, the effects of 2 sessions of 12 hours'CES were examined. The results was this ; adrenal catecholamines, especially adrenaline decreased, blood sugar and NEFA tended to increase, and serum IRI decreased. 4) These results suggest that the emotional stress, especially through the activation of sympathetico-adrenomedullary system, exert manifest influences on glucose metabolism in normal rats and in alloxan-diabetic rats. Some theoretical considerations were done concerning the mechanisms of the appearance of the above-mentioned changes in blood chemistry.
日本心身医学会の論文

アロキサン糖尿病に及ぼす条件情動ストレスの影響

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