<原著>消化管X線検査におけるGlucagonの効果と副作用 : その1 胃十二指腸検査

概要

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Glucagon, a gastrointestinal hormone produced in the pancreatic α-cells, has a wide range of physiological effects. In this report, the gastrointestinal radiology was assessed for the role of glucagon, and the efficacy was compared with an anti-cholinergic agent. Patients who undergo gastrointestinal tests were divided into two groups at random. Physical background of each group was almost the same. In one group of 17 patients, 1 U.S.P. of glucagon, and in the other group of 25 patients, 20 mg of butylscopolamine bromide was administered intramuscularly before intake of Ba, respectively. Hypotonia, suppression of peristalsis, Ba coating and picture of fine relief were examined on X-ray films, for comparison. Blood pressure and heart rate were recorded before and after administration of the agents. Complaints were also listed. Although the two groups showed no significant difference in the spasmolytic action on stomach, glucagon was slightly less effective for obtaining a fine relief of stomach. Glucagon raisd blood pressure slightly, but had no effect on heart rate. Glucagon had also no significant side effect on patients with heart diseases and complaints could be negligible. These results suggest that glucagon which is free from contraindication and adverse effects may widely serve as a good premedication even in patients with heart diseases who are subjected to upper gastrointestinal examination.
近畿大学の論文
1984-09-25