血圧調節中枢である延髄孤束核における神経伝達物質の関与について(I 発生病理)(A 基礎的研究)

概要

論文の詳細を見る
We used the immunocytochemical method to examine the difference in the morphology of catecholaminergic cell bodies of the solitary nucleus between stroke-prone spontaneously hypertensive rats (SHR-SP) and Wistar Kyoto rats (WKY). The average cross-sectional area of catecholaminergic cell bodies in SHR-SP was smaller than that in WKY. This may suggest that catecholaminergic cells in the solitary nucleus are morphologically influenced by the hypertensive condition. Next, we used the immunoelectron microscopic mirror technique to demonstrate the synaptic relationship between neuronal structures containing catecholamines and substance P (SP), or catecholamines and cholecystokinin (CCK) in the solitary nucleus in Wistar rats. Either SP- or CCK-immunoreactive axon terminals were shown to make synaptic contacts with catecholaminergic cells. Thus it is concluded that SP and CCK afferents can directly affect catecholaminergic cells in this nucleus via synapses.
近畿大学の論文
1985-12-30