<原著>小児の各種糸球体疾患における凝固線溶系諸因子の変動について(第1報)

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Coagulation and fibrino1ytic system were studied in total 42 cases with various glomerular diseases such as acute glomerulonephritis (11 cases), persistent glomerulonephritis (11 cases), purpura nephritis (5 cases), hereditary nephritis (5 cases), idiopathic nephritic nephrosis (5 cases) and lipoid nephrosis (5 cases). The levels of plasma fibrinogen and serum α-2 macroglobulin were raised in patients with nephrotic syndrome. Plasma fibrinogen was considerably related to the levels of serum albumin and urinary protein. These abnormalities suggest hypoplasminoactivity in nephrotic syndrome. Urinary FDP (fibrin/fibrinogen degradation products) was raised in the early stages of acute glomerulonephritis, and purpura nephritis and hereditary nephritis with nephrotic syndrome, and idiopathic nephritic nephrosis, but was not detected in persistent glomerulonephritis and lipoid nephrosis. Serial determination of urinary FDP appeared to be a reliable indicator of the activity and progression in glomerulonephritis. The levels of plasma plasminogen and plasmin were measured by Lysine-Sepharose affinity chromatography, and showed no definite trend of the activity in glomerular diseases.
1976-11-30