COMPARISON OF NITROGEN DIOXIDE PRODUCTION DURING INHALED NITRIC OXIDE THERAPY WITH HIGH FREQUENCY OSCILLATORY VENTILATION AND INTERMITTENT MANDATORY VENTILATION

概要

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We compared the production of nitrogen dioxide (NO_2) in the ventilatory circuit when high frequency oscillatory ventilation (HFOV) is used as the mode of mechanical ventilation versus intermittent mandatory ventilation (IMV). This study was performed using Humming V ventilator with a neonatal circuit and a 50 ml silicone test lung. Nitric oxide (NO) gas was administrated into the inspiratory limb at a distance of 80 cm from the Y piece, which was connected to the adapter of the endotracheal tube. The tubes used for the NO administration line were two sizes 6 mm/4 mm (ID-4) and 4 mm/2 mm (ID-2) in the outer/inner diameter. When the NO concentrations measured at the Y piece were 1,2,5,10,20,30 and 40 ppm, the NO_2 concentrations at the same place were simultaneously measured. The NO_2 concentrations in the combination of the HFOV/ID-4 were significantly higher than those in the combinations of the IMV/ID-4,the IMV/ID-2 and the HFOV/ID-2 in all of the NO concentrations except 30 ppm and 40 ppm. This occurs because the back and forth movements of the gas generated by the oscillation had an influence on the mixing of the NO and oxygen gases in the NO administration line.
名古屋市立大学の論文
2000-11-01