<Originals>Integrin expression by Hymenolepis nana oncosphere-derived eosinophil chemotactic factor in parasite-induced eosinophilia
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概要
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To examine the mechanism that enable selective eosinophil migration in parasitic infection, the interplay between adhesion molecules and chemoattractant was studied in eosinophils in response to Hymenolepis nana oncospheres by flow cytometry analysis and by in vitro and in vivo chemotaxis assay. Increased expression of surface adhesion molecules, particularly CD11b, CD18 and CD49d, was observed on eosinophils, but not on neutrophils, from the peritoneal cavity of mice injected with a soluble extract of H. nana oncospheres, as compared with blood eosinophils. In addition, purified blood eosinophils cultured with various concentrations of oncosphere extract, but not neutrophils, presented a dose-dependent up-regulation of CD11b, CD18 or CD49d. In similar experiments using immunized mice by an oral administration of the eggs, peritoneal and blood eosinophils revealed the increased expression of adhesion molecules, especially CD49d and CD54,compared with those in uninfected mice. The oncosphere extract also showed chemotactic activity specific for eosinophils but not for neutrophils. Partially purified eosinophil chemotactic factors (ECFs) from the oncosphere extract showed an apparent molecular mass from 5.5 to 9.6 kDa and 30 to 40 kDa. The chemotactic activity for eosinophils was not separable from the adhesion molecule expression by means of chromatographies. These findings indicate that the capacity of H. nana oncosphere-derived molecules to stimulate both eosinophil chemotaxis and enhanced expression of integrins could be important in the pathogenesis of the parasitic infection.
- 近畿大学の論文
著者
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NIWA Atsuko
Department of Immunology, Kinki University School of Medicine
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Niwa Atsuko
Department Of Immunology Kinki University School Of Medicine
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