Production of Anti-Amyloid β Antibodies in Mice Fed Rice Expressing Amyloid β

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概要

• 論文の詳細を見る

• The main signs of Alzheimer’s disease (AD) are cognitive impairment and senile plaques composed of amyloid beta (Aβ) observed in patients’ brains. Therefore, therapy for AD focuses on the removal of Aβ. We developed an “edible vaccine” that employs intestinal immunity with little to no side effects. Rice was utilized as an edible vaccine. It expressed GFP-Aβ42. Aβ rice was administered orally to wild-type (WT) mice causing production of anti-Aβ antibodies. Since Aβ rice was mixed with the cholera toxin B subunit (CTB), antibody against the rice seed protein was also produced. Then, mice were caused to develop immune tolerance against the rice seed protein by oral administration of Aβ rice mixed with CTB. The results indicated that only anti-Aβ antibodies were produced.

• 2011-02-23

著者

• Watanabe Yuichiro

  Department of Life Science, Graduate School of Arts and Sciences, University of Tokyo

• NOJIMA Jun

  Department of Life Science, Graduate School of Arts and Science, The University of Tokyo

• ISHII-KATSUNO Rika

  Department of Life Science, Graduate School of Arts and Science, The University of Tokyo

• FUTAI Eugene

  Department of Life Science, Graduate School of Arts and Science, The University of Tokyo

• SASAGAWA Noboru

  Department of Life Science, Graduate School of Arts and Science, The University of Tokyo

• YOSHIDA Taiji

  Local Crop Research Team, National Agricultural Research Center for The Tohoku Region

• ISHIURA Shoichi

  Department of Life Science, Graduate School of Arts and Science, The University of Tokyo

• Sasagawa Noboru

  Department Of Agricultural Chemistry The University Of Tokyo

• Ishiura Shoichi

  Department Of Life And Cognitive Sciences College Of Arts And Sciences The University Of Tokyo

• Nojima Jun

  Department Of Life Science Graduate School Of Arts And Science The University Of Tokyo

• Ishii Katsuno

  Department Of Life Science Graduate School Of Arts And Science The University Of Tokyo

• Futai Eugene

  Department Of Life Science Graduate School Of Arts And Science The University Of Tokyo

• Ishiura Shoichi

  Department Of Life Science Graduate School Of Arts And Science The University Of Tokyo

• Sasagawa Noboru

  Department Of Life Science Graduate School Of Arts And Science The University Of Tokyo

• Yoshida Taiji

  Local Crop Research Team National Agricultural Research Center For The Tohoku Region

• Watanabe Yuichiro

  Department Of Life Science Graduate School Of Arts And Science The University Of Tokyo

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