Production of Anti-Amyloid β Antibodies in Mice Fed Rice Expressing Amyloid β
スポンサーリンク
概要
- 論文の詳細を見る
The main signs of Alzheimer’s disease (AD) are cognitive impairment and senile plaques composed of amyloid beta (Aβ) observed in patients’ brains. Therefore, therapy for AD focuses on the removal of Aβ. We developed an “edible vaccine” that employs intestinal immunity with little to no side effects. Rice was utilized as an edible vaccine. It expressed GFP-Aβ42. Aβ rice was administered orally to wild-type (WT) mice causing production of anti-Aβ antibodies. Since Aβ rice was mixed with the cholera toxin B subunit (CTB), antibody against the rice seed protein was also produced. Then, mice were caused to develop immune tolerance against the rice seed protein by oral administration of Aβ rice mixed with CTB. The results indicated that only anti-Aβ antibodies were produced.
著者
-
Watanabe Yuichiro
Department of Life Science, Graduate School of Arts and Sciences, University of Tokyo
-
NOJIMA Jun
Department of Life Science, Graduate School of Arts and Science, The University of Tokyo
-
ISHII-KATSUNO Rika
Department of Life Science, Graduate School of Arts and Science, The University of Tokyo
-
FUTAI Eugene
Department of Life Science, Graduate School of Arts and Science, The University of Tokyo
-
SASAGAWA Noboru
Department of Life Science, Graduate School of Arts and Science, The University of Tokyo
-
YOSHIDA Taiji
Local Crop Research Team, National Agricultural Research Center for The Tohoku Region
-
ISHIURA Shoichi
Department of Life Science, Graduate School of Arts and Science, The University of Tokyo
関連論文
- In Planta Production of Immunogenic Poliovirus Peptide Using Tobacco Mosaic Virus-Based Vector System(PLANT BIOTECHNOLOGY)
- Production of Anti-Amyloid β Antibodies in Mice Fed Rice Expressing Amyloid β
- Coexpression of the CUG-Binding Protein Reduces DM Protein Kinase Expression in COS Cells
- Interaction between Emerin and Nuclear Lamins
- Catalog of Micro-Tom tomato responses to common fungal, bacterial, and viral pathogens
- The Generation of Monoclonal Antibodies against Human Peroxisome Proliferator-activated Receptors(PPARs)
- Preparation and Properties of Tetra- and Octa-substituted Phthalocyanines with Cationic Trimethylaniliniumyl Groups
- Construction and Some Characterization of a Yeast Artificial Chromosome Library from DNA of a Tomato Line Having Four Disease Resistance Traits
- Design of BACE1 Inhibitors : Replacing the P_1' Residue with Non-Acidic Moiety
- Design of β-Secretase (BACE1) Inhibitors with Carboxylic Acid Bioisosteres
- Design and Synthesis of β-Secretase Inhibitors Containing Hydroxymethylcarbonyl Isostere as a Transition State Mimic
- Aspergillus oryzae palB^ Encodes a Calpain-Like Protease : Homology to Emericella nidulans PalB and Conservation of Functional Regions
- A decrease in interleukin-1 receptor antagonist expression in the prefrontal cortex of schizophrenic patients
- Limited Proteolysis of Filamin Is Catalyzed by Caspase-3 in U937 and Jurkat Cells^1
- Autolysis of Calpain Large Subunit Inducing Irreversible Dissociation of Stoichiometric Heterodimer of Calpain
- SAR study of BACE1 inhibitors containing pyridine derivatives
- Denervation Enhances the Expression of SHPS-1 in Rat Skeletal Muscle
- Expression of ARPP-16/19 in Rat Denervated Skeletal Muscle
- The First Molecular Evidence That Autophagy Relates Rimmed Vacuole Formation in Chloroquine Myopathy
- Altered expression of CUG binding protein 1 mRNA in myotonic dystrophy 1 : possible RNA-RNA interaction
- Use of Green Fluorescent Protein as a Molecular Tag of Protein Movement In vivo
- Quantitative Analysis of CUG-BP1 Binding to RNA Repeats
- Identification and Characterization of the Hesr1/Hey1 as a Candidate trans-Acting Factor on Gene Expression through the 3' Non-Coding Polymorphic Region of the Human Dopamine Transporter (DAT1) Gene
- Overexpression of Human Myotonic Dystrophy Protein Kinase in Schizosaccharomyces pombe Induces an Abnormal Polarized and Swollen Cell Morphology
- Expression of Human ADAM9, ADAM10 and ADAM17 in COS-7 cells
- -0324-CIRCADIAN CHARACTERISTICS OF VENTRICULAR ECTOPY (VE) IN CORONARY ARTERIAL DISEASE (CAD) AND MYOCARDIOPATHY (M)
- Location of a Possible miRNA Processing Site in SmD3/SmB Nuclear Bodies in Arabidopsis
- Function of ADAM9 in Xenopus Embryos
- A virus-induced gene silencing approach for the suppression of nicotine content in Nicotiana benthamiana
- Use of an Attenuated Strain of Tobamovirus for Early Detection of Virus-Induced Gene Silencing
- Improved Gateway Binary Vectors : High-Performance Vectors for Creation of Fusion Constructs in Transgenic Analysis of Plants
- Study on a soluble splicing variant of human ADAM9
- No association between the ERBB3 gene and schizophrenia in a Japanese population
- Production of Anti-Amyloid β Antibodies in Mice Fed Rice Expressing Amyloid β
- The tryptophan hydroxylase 1 (TPH1) gene and risk of schizophrenia : A moderate-scale case-control study and meta-analysis
- No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population
- Construction of a Tobamovirus Vector That Can Systemically Spread and Express Foreign Gene Products in Solanaceous Plants
- Context Analysis of Termination Codons in mRNA that are Recognized by Plant NMD
- The Mechanism Selecting the Guide Strand from Small RNA Duplexes is Different Among Argonaute Proteins