Expression of ARPP-16/19 in Rat Denervated Skeletal Muscle

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概要

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• It is known that denervation of rat skeletal muscle causes atrophy and this is often adopted as a model for human muscle atrophy. To understand the molecular changes that occur, it is important to identify the profiles of differential gene expression. In the present study, we investigated differentially expressed genes in denervated muscle using DNA microarrays with printed genes preferentially expressed in skeletal muscle. We found that several genes are differentially expressed. Of these genes, ARPP-16/19 (cAMP-regulated phosphoprotein 16/19) is selectively enhanced after denervation. The expression of ARPP-16/19 in denervated muscles starts to increase from two days after denervation surgery. On the other hand, the expression of ARPP-16/19 does not change in hind-limb suspended muscles, such as EDL and soleus muscles. These results suggest that the increase in ARPP-16/19 mRNA expression is regulated by unknown factor (s) secreted from nerves, and not by electrical muscle activity.

• 社団法人 日本生化学会の論文

著者

• Goto Yu-ichi

  Department Of Child Neurology National Center Hospital For Mental Nervous And Musculardisorders Nati

• Yoshikawa Ayumu

  Department Of Life Sciences Graduate School Of Arts And Sciences The University Of Tokyo

• Sasagawa Noboru

  Department Of Agricultural Chemistry The University Of Tokyo

• Nishino Ichizo

  Department Of Neuromuscular Disorders National Institute Of Neuroscience National Center Of Neurolog

• Tsukahara Toshifumi

  Department Of Neuromuscular Research National Institute Of Neuroscience National Center Of Neurology

• Hayashi Yukiko

  Department Of Internal Medicine Asama General Hospital

• Mitsuhashi Hiroaki

  Department Of Life Sciences Graduate School Of Arts And Sciences The University Of Tokyo

• Ishiura Shoichi

  Department of Biochemistry , Graduate School of Pharmaceutical Sciences. Hokkaido University

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