The First Molecular Evidence That Autophagy Relates Rimmed Vacuole Formation in Chloroquine Myopathy.

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概要

• 論文の詳細を見る

• Chloroquine myopathy is a drug poisoning disease involving rimmed vacuole formation. By Western blot analysis, we investigated posttranslational modification of LC3 in cultured cells with a high concentration of chloroquine, and found that the autophagosome membrane-bound form of LC3 increased dose-dependently. We also constructed a disease model by excessive chloroquine injection into rats and unusual immunohistochemical alteration was chased using anti-LC3 antibodies. With chloroquine treatment, muscle atrophy occurred predominantly in soleus muscle and unusual autophagosomes were accumulated. Therefore, we concluded that autophagy plays an important role in rimmed vacuole formation in certain muscular atrophies.

• 社団法人 日本生化学会の論文

著者

• Yoshikawa Ayumu

  Department Of Life Sciences Graduate School Of Arts And Sciences The University Of Tokyo

• Sasagawa Noboru

  Department Of Agricultural Chemistry The University Of Tokyo

• Ishiura Shoichi

  Department Of Life And Cognitive Sciences College Of Arts And Sciences The University Of Tokyo

• Ohsumi Yoshinori

  Division Of Bioenergetics Department For Cell Biology National Institute Of Basic Biology

• Nonaka Ikuya

  Department Of Child Neurology National Center Hospital For Mental Mervous And Muscular Disorders Ncn

• Nishino Ichizo

  Department Of Neuromuscular Disorders National Institute Of Neuroscience National Center Of Neurolog

• Yoshimori Tamotsu

  Division Of Bioenergetics Department For Cell Biology National Institute Of Basic Biology

• Nakagawa Masahiro

  Deparment Of Electrical Engineering Faculty Of Engineering Nagaoka University Of Technology

• Suzuki Takashi

  Department Of Anatomic Pathology Tohoku University School Of Medicine

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