Diagnostic Performance of ADC for Non-mass-like Breast Lesions on MR Imaging
スポンサーリンク
概要
- 論文の詳細を見る
We assessed the usefulness and limitations of utilizing apparent diffusion coefficient (ADC) values on diffusion-weighted imaging (DWI) for the differential diagnosis of benign and malignant non-mass-like breast lesions. We retrospectively reviewed 27 such lesions (16 malignant, 11 benign) detected on magnetic resonance (MR) imaging and analyzed the enhancing patterns of dynamic contrast-enhanced DCE-MRI (distribution and internal enhancement), kinetic curve patterns, and ADC values. All images were obtained with a 1.5-tesla MR unit, with patients supine. On DCE-MRI, malignant lesions tended to show either segmental or branching-ductal distribution, and when lesions with these patterns were considered malignant, sensitivity was 68.8%; specificity, 63.6%; positive predictive value (PPV), 73.3%; negative predictive value (NPV), 58.3%; and accuracy, 66.7%. Kinetic curve analysis did not reliably differentiate benign and malignant non-mass-like lesions. There was no significant difference between the mean ADC value of the malignant lesions, 0.968×10−3 mm2/s at b=1000 s/mm2, and that of benign lesions, 1.207×10−3 mm2/s (P=0.109). Receiver operating characteristic (ROC) analysis revealed the most effective threshold of ADC value for differentiating tumors as 1.1×10−3 mm2/s; values lower than this were observed more often in malignant than benign lesions (P=0.054). Us of this threshold yielded sensitivity of 68.8%; specificity, 72.7%; PPV, 78.6%; NPV, 61.5%; and accuracy, 70.4%. Combining the ADC value criteria with the analysis of DCE-MRI pattern increased sensitivity to 93.8%, negative predictive value (NPV) to 85.7%, and accuracy to 77.8% but decreased specificity to 54.5%. Use of ADC values does not adequately improve DCE-MRI performance for differential diagnosis of non-mass-like breast lesions, but adding the ADC value criteria to the DCE-MRI pattern analysis improves sensitivity, NPV, and accuracy.
- 2010-12-01
著者
-
Honda Sumihisa
Department Of International Health Institute Of Tropical Medicine Nagasaki University
-
HAYASHI Tomayoshi
Nagasaki University Hospital
-
Isomoto Ichiro
Department Of Radiology Nagasaki University Graduate School Of Biomedical Sciences
-
Yano Hiroshi
Department Of Surgery Ntt West Osaka Hospital
-
Abe Kuniko
Department Of Pathology Nagasaki University Hospital
-
Abe Kuniko
Department Of Clinical Pathology Nagasaki University Hospital
-
Hayashi Tomayoshi
Department Of Cardiovascular Surgery And Pathology Nagasaki University School Of Medicine
-
Hayashi Tomayoshi
Deaprtment Of Pathology Nagasaki University Hospital
-
Uetani Masataka
Department Of Radiological Sciences Nagasaki University Graduate School Of Biomedical Sciences
-
IMAMURA Tsugumi
Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences
-
SUEYOSHI Eijun
Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences
-
UGA Tatsuya
Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences
-
YAMAGUCHI Takuma
Department of Radiology, Nagasaki Miharadai Hospital
-
Uga Tatsuya
Department Of Surgery Nagasaki University Graduate School Of Biomedical Sciences
-
Sueyoshi Eijun
Department Of Radiological Sciences Nagasaki University Graduate School Of Biomedical Sciences
-
Imamura Tsugumi
Department Of Radiological Sciences Nagasaki University Graduate School Of Biomedical Sciences
-
Yamaguchi Takuma
Department Of Radiology Nagasaki Miharadai Hospital
-
Isomoto Ichiro
Department Of Radiological Sciences Nagasaki University Graduate School Of Biomedical Sciences
-
Yano Hiroshi
Department Of Surgical Oncology Nagasaki University Graduate School Of Biomedical Sciences
-
Hara Takeshi
Department Of Cell Physiology Atomic Disease Institute Nagasaki University School Of Medicine
-
Yano Hiroshi
Department Of Agricultural Chemistry Tohoku University
-
Uetani Masataka
Department Of Radiological Science Nagasaki University Graduate School Of Biomedical Sciences
-
Isomoto Ichiro
Department Of Radiological Science Nagasaki University Graduate School Of Biomedical Sciences
-
Honda Sumihisa
Department of Cardiopulmonary Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan
関連論文
- Post-Traumatic Stress Disorder Among Senior Victims of Tsunami-Affected Areas in Southern Sri Lanka
- Allogeneic stem cell transplantation versus chemotherapy as post-remission therapy for intermediate or poor risk adult acute myeloid leukemia : results of the JALSG AML97 study
- Oncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cells
- Immunohistochemical analysis of connexin43 expression in infertile human testes.
- Hepatitis B Related Polyarteritis Nodosa Presenting Necrotizing Vasculitis in the Hepatobiliary System Successfully Treated with Lamivudine, Plasmapheresis and Glucocorticoid
- Determinants of Self-Rated Health among Community-Dwelling Women Aged 40 Years and over in Japan
- Secular Trends of Sizes at Birth in Japanese Healthy Infants Born between 1962 and 1988
- Lung fibrosis 10 years after cessation of bleomycin therapy.
- Primary High-Grade Myofibroblastic Sarcoma Arising From the Pericardium
- Importance of the Retro-Mammary Space as a Route of Breast Cancer Metastasis
- Mental health conditions among atomic bomb survivors in Nagasaki
- Effects of Lifestyle Factors on Stiffness Index of Calcaneus Measured by Quantitative Ultrasound System among Japanese Women Aged 40 Years and Over : The Hizen-Oshima Study
- Demographic and Reproductive Factors for High Seroprevalence of Chlamydia Trachomatis among Pregnant Women in Japan
- Intraductal papillary neoplasm of the bile duct extending superficially from the intrahepatic to extrahepatic bile duct
- Risk of Development of Abdominal Aortic Aneurysm and Dissection of Thoracic Aorta in a Postpartum Womanwith Marfans Syndrome
- Elevated Levels of Tenascin-C in Patients with Cryptogenic Organizing Pneumonia
- Primary hepatic carcinoid tumor
- Nonspecific Interstitial Pneumonia with Poor Prognosis Associated with Amyopathic Dermatomyositis
- Recent Progress in SiC Ion Implantation and MOS Technologies for High Power Devices
- High Channel Mobility in Inversion Layer of SiC MOSFETs for Power Switching Transistors
- High Channel Mobility in Inversion Layer of SiC MOSFETs for Power Switching Transistors
- Segmental Jumping Translocation of Ret Oncogene in Radiation-associated Thyroid Cancer
- Chondrosarcoma of the patella
- Mucosa-Associated Lymphoid Tissue Lymphoma of the Thymus Associated with Sjogren's Syndrome : Report of a Case
- Contrast-Enhanced Dynamic Magnetic Resonance Imaging of Primary Pulmonary Leiomyosarcoma
- Chest Wall Invasion by Peripheral Lung Cancer: Preoperative Assessment with Respiratory Dynamic MRI
- Enteropathy-Type Intestinal T-Cell Lymphoma Showing Jejunoileal Fistula: Report of a Case
- Expression and Significance of Angiopoietin-1, 2 and Tie-2 Receptor in Human Extrahepatic Bile Duct Carcinoma: Correlation with Clinicopathological Factors
- Ruptured Aneurysm of the Visceral Artery : Report of Two Cases
- Peripheral T-cell lymphoma with a nodular growth pattern
- Amyloid a Protein Amyloidosis in a Patient with Plasma Cell Dyscrasia
- A case of cold agglutinin disease in the course of treatment for polymyalgia rheumatica
- Elevation of Serum KL-6 Glycoprotein or Surfactant Protein-D in Adult T-cell Leukemia with Distinct Pulmonary Complications
- Magnetic resonance imaging in a patient with peripartum cardiomyopathy.
- Chemosensitivity of a Recurrent Desmoid Tumor with Increased Osteopontin Expression and a Novel Frame-Shift Mutation at Codon 1564 of the APC Gene
- Histological analysis of the ligamentum flavum of patients with dialysis-related spondyloarthropathy
- Serum Levels of S-Glutathionylated Proteins as a Risk-Marker for Arteriosclerosis Obliterans
- Association of Age, Obesity, Joint Pain, and Chewing Ability with Chair Stand Difficulty among Community-dwelling Elderly People in Nagasaki, Japan
- 30-III-06 Estrogen receptor-associated expression of keratinocyte growth factor and its possible role in the inhibition of the induction of apoptosis in human breast cancer(THE JOINT MEETING OF THE 44TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTR
- The Effects of a Health Promotion Program on Body Mass Index
- Cancer Mortality in Nagasaki Atomic Bomb Survivors with Epilation
- Incidence of multiple primary cancers in Nagasaki atomic bomb survivors: association with radiation exposure.
- A case of pleomorphic carcinoma of the lung
- Attenuated Familial Adenomatous Polyposis Associated with Advanced Rectal Cancer in a 16-Year-Old Boy : Report of a Case
- Small-Cell Carcinoma of the Gallbladder : Report of a Case
- Multiple Primary Cancers in Nagasaki Atomic Bomb Survivors
- Vitamin D3 Treatment for Locally Advanced Thyroid Cancer : A Case Report
- GASTRIC SUBMUCOSAL HETEROTOPIA OF THE IMMATURE GASTRIC GLANDS WITH ENDOSCOPIC FEATURE MIMICKING CARCINOID TUMOR
- A Case of Intravascular Large B-cell Lymphoma (IVLBCL) with no Abnormal Findings on Chest Computed Tomography Diagnosed by Random Transbronchial Lung Biopsy
- Deep Interface States in SiO_2/p-type α-SiC Structure
- GASTRIC LIPOMA SUCCESSFULLY REMOVED BY LAPAROSCOPIC INTRAGASTRIC SURGERY
- LAPAROSCOPIC TREATMENT FOR PERFORATED APPENDICITIS WITH PELVIC ABSCESS
- Double Congenital Bronchoesophageal Fistulae in an Adult
- USE OF NON-POWDER SURGICAL GLOVE FOR EXTRACTIO OF GALLBLADDER IN LAPAROSCOPIC CHOLECYSTECTOMY
- LAPAROSCOPIC CHOLECYSTECTOMY FOR ASYMPTOMATIC CHOLELITHIASIS
- Efficacy of Absorbable Clips Compared with Metal Clips for Cystic Duct Ligation in Laparoscopic Cholecystectomy
- Laparoscopic Wedge Resection for Gastric Perforation After Endoscopic Mucosal Resection : Report of a Case
- Solitary Splenic Metastasis from Ovarian Cancer Successfully Treated by Hand-Assisted Laparoscopic Splenectomy : Report of a Case
- The Usefulness, Indications, and Complications of Laparoscopy-Assisted Colectomy in Comparison with Those of Open Colectomy for Colorectal Carcinoma
- Laparoscopic Surgery for Blind Pouch Syndrome Following Roux-en Y Gastrojejunostomy: Report of Case
- Segmental Mediolytic Arteriopathy Involving Celiac to Splenic and Left Renal Arteries
- Duodenocolic Fistula Originating from Ascending Colon Cancer in the Blind Loop
- Current and Future Strategy for Breast Cancer Treatment at Nagasaki University Hospital
- Establishment and Characterization of a Malignant Epithelioid Hemangioendothelioma from Mouse Thyroid Tumor
- OE-297 Is Soluble Lectin-like Oxidized Low-density Lipoprotein Receptor-1 a Good Indicator for Early Detection of Myocardial Fibrosis in Hypertrophic Cardiomyopathy?(Cardiomyopathy, basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circ
- Expression of keratinocyte growth factor and its receptor in human breast cancer : its inhibitory role in the induction of apoptosis possibly through the overexpression of Bcl-2
- II-B-15 Estrogen receptor-associted expression of keratinocyte growth factor (KGF) and its possible involvement in the regulation of cell kinetics in human breast cancer in vivo and in vitro(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY A
- Unicentric Castleman's disease with leiomyosarcoma : A rare association
- Potential of Magnetic Resonance Plaque Imaging Using Superparamagnetic Particles of Iron Oxide for the Detection of Carotid Plaque
- Immunohistochemical and Lectin-Histochemical Patterns of Renal Non-Neoplastic and Neoplastic Epithelium: Utility of the Patterns in the Differential Diagnosis of Renal Epithelial Tumors
- Mucinous adenocarcinoma of the renal pelvis associated with transitional cell carcinoma in the renal pelvis and the bladder
- Primary renal angiosarcoma : A case report and review of the literature
- Personality Traits of Patients with Chronic Obstructive Pulmonary Disease Who Exhibit Depression
- Immunohistochemical localization of the ACTH (MC-2) receptor in the rat placenta and adrenal gland
- A-12 Immunohistochemical localizaition of ACTH receptor in rat placenta and adrenal gland tissues
- Extensive Resection of Invasive Recurrent Left Parotid Gland Carcinoma ex Pleomorphic Adenoma
- Papillary Tumor of the Pineal Region
- Large Cell Neuroendocrine Carcinoma of the Stomach
- Prevalence and involvement patterns of radiographic hand osteoarthritis in Japanese women : the Hizen-Oshima Study
- Nagasaki Schizophrenia Study: Influence of the Duration of Untreated Psychosis on Long-Term Outcome
- The prevalence and pattern of insomnia in Japanese industrial workers : Relationship between psychosocial stress and type of insomnia
- Anticipation in Japanese families with schizophrenia
- Cutaneous vasculitis induced by TNF inhibitors : a report of three cases
- A Case of Mixed Medullary and Follicular Cell Carcinoma of the Thyroid
- Granular Cell Tumor of the Breast: A Case Report Describing Dynamic MR Mammography
- A Long Term Survival Case of Thymic Squamous Cell Carcinoma, Perfomed Complete Extirpation With Vascular Reconstruction of the Superior Vena Cava
- Partial Left Ventriculectomy for End-stage Cardiomyopathy : Report of a Case
- Specificity of a New Metalloproteinase form Penicillium citrinum(Biological Chemistry)
- Endoscopic Sinus Surgery in Cases of Cholesterol Granuloma of the Maxillary Sinus
- Intraosseous carcinoma of the mandible composed of cells expressing myoepithelial cell-associated antigens
- Placental multiple chorionic cysts in maternal scleroderma
- Patient allocation based on preoperative assessment of pancreatic fibrosis to secure pancreatic anastomosis performed by trainee surgeons : a prospective study
- Diagnostic Performance of ADC for Non-mass-like Breast Lesions on MR Imaging
- Intraductal papillary growth of liver metastasis originating from colon carcinoma in the bile duct: report of a case.
- Model Building Method for Time Series with High Complexity Using Genetic Programming
- Adenosquamous Carcinoma Arising in a Thyroglossal Duct Cyst : Report of a Case
- Factors associated with radiographic osteoarthritis of the knee among community-dwelling Japanese women : the Hizen-Oshima Study
- Putative IgG4-related pituitary disease with hypopituitarism and/or diabetes insipidus accompanied with elevated serum levels of IgG4
- Spindle Cell Carcinoma of the Breast : MR Findings Correlated with Histopathology
- Cardiogenic Shock due to Left Ventricular Outflow Obstruction and Complete Atrioventricular Block in a Patient with Hypertrophic Cardiomyopathy with Acute Myocarditis