Potential of Magnetic Resonance Plaque Imaging Using Superparamagnetic Particles of Iron Oxide for the Detection of Carotid Plaque
スポンサーリンク
概要
- 論文の詳細を見る
Macrophages and by-products are important in plaque destabilization in atherosclerosis. Ultra-small superparamagnetic particles of iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging may be suitable for the detection of macrophages in atherosclerotic plaques. The present study investigated the potential of MR plaque imaging using SPIO in 10 patients scheduled for carotid endarterectomy before and 24-43 hours after administration of SPIO (fercarbotran, 0.016 ml/kg). Three-dimensional gradient recalled acquisition in the steady state (3D-GRASS) was used for detecting macrophages within plaques. Signal loss on the post-contrast 3D-GRASS images was found in 5 of 10 cases, and accumulation of SPIO particles in the vessel wall was confirmed in 4 of these 5 cases. Intracytoplasmic localization of SPIO particles within recruited macrophages was verified by double staining analysis. A correlation between MR plaque imaging using SPIO and localization of macrophages was demonstrated in 6 of 10 patients. This study indicates that MR plaque imaging using SPIO is a potential functional imaging tool to detect infiltration of macrophages in human atherosclerotic carotid plaque.
- 社団法人 日本脳神経外科学会の論文
- 2008-04-15
著者
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Nagata Izumi
Department Of Neurosurgery Faculty Of Medicine Kyoto University
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Nagata Izumi
Department Of Neurosurgery Nagasaki University Graduate School Of Biomedical Sciences
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HAYASHI Tomayoshi
Department of Pathology, Nagasaki University Hospital of Medicine and Dentistry
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Nagata Izumi
Department Of Neurosurgery Nagasaki University School Of Medicine
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Kitagawa Naoki
Department Of Neurosurgery Nagasaki University School Of Medicine
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Morikawa Minoru
Department of Radiology, Nagasaki University School of Medicine
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Morikawa Minoru
Department Of Radiology Nagasaki University Graduate School Of Biomedical Sciences
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TSUTSUMI Keisuke
Department of Neurosurgery, Nagasaki Rosai Hospital
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KAWAHARA Ichiro
Department of Neurosurgery, National Nagasaki Medical Center
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Kawahara Ichiro
Department Of Neurosurgery Nagasaki Prefectural Shimabara Hospital
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Kawahara Ichiro
Departments Of Neurosurgery Nagasaki University School Of Medicine:(present Office)department Of Neu
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NAKAMOTO Morito
Departments of Neurosurgery, Nagasaki University School of Medicine
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Nakamoto Morito
Department Of Neurosurgery Nagasaki Prefecture Shimabara Hospital
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Nakamoto Morito
Departments Of Neurosurgery Nagasaki University School Of Medicine
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Tsutsumi Keisuke
Department Of Neurosurgery Nagasaki University Graduate School Of Biomedical Sciences
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Tsutsumi Keisuke
Department Of Neurosurgery Nagasaki Rosai Hospital
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Hayashi Tomayoshi
Departments Of Clinical Pathology Nagasaki University School Of Medicine
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Hayashi Tomayoshi
Department Of Cardiovascular Surgery And Pathology Nagasaki University School Of Medicine
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Morikawa Minoru
Department Of Diagnosis Radiology University Of Martland Medical System
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Kitagawa Naoki
Department Of Neurosurgery Nagasaki University Graduate School Of Biomedical Sciences
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Kawahara Ichiro
Department of Industrial Chemistry, School of Engineering, Okayama University
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