Plasma Adiponectin Level and Myocardial Infarction : the JMS Cohort Study
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概要
- 論文の詳細を見る
Background: Adiponectin is associated with many cardiovascular risk factors. Thus, a relation between adiponectin and subsequent coronary heart disease has been hypothesized. However, the results of prospective studies have been conflicting.Methods: In this nested case-control study, blood samples were collected from 5243 of 12 490 community residents enrolled in the Jichi Medical School Cohort Study. The samples were taken between 1992 and 1995 and stored until 2007, at which point the plasma adiponectin level was measured.Results: During an average of 9.4 years of follow-up, 38 patients with myocardial infarction and 89 controls matched for age, sex, and community were identified. Plasma adiponectin concentration did not significantly differ between cases and controls (geometric mean 7.6 [interquartile range, 5.0–12.2] versus 7.4 [5.4–11.0] mg/L, respectively, P = 0.57). The odds of myocardial infarction in the lowest tertile of adiponectin concentration was not significantly different from that in the highest tertile, after adjustment for age and sex (OR 1.33; 95% CI, 0.50–3.55) or after further adjustment for other cardiovascular risk factors (OR 1.68; 95% CI, 0.45–6.25). Similarly, there was no significant difference in odds of myocardial infarction between the lowest and highest quartiles of adiponectin concentration.Conclusion: The results do not support an association between hypoadiponectinemia and myocardial infarction.
- 日本疫学会の論文
- 2009-03-01
著者
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ISHIKAWA Shizukiyo
Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University
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KAJII Eiji
Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University
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Ishikawa Shizukiyo
Division Of Community And Family Medicine Center For Community Medicine Jichi Medical University
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Ishikawa Shizukiyo
自治医科大学 医学部循環器内科学
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Ishikawa Shizukiyo
自治医科大学地域医療学センター
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Ishikawa Shizukiyo
自治医科大学地域医療学センター 地域医療学部門
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MATSUMOTO Masatoshi
Division of Community and Family Medicine, Centre for Community Medicine, Jichi Medical University
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Kajii Eiji
Division Of Community And Family Medicine Center For Community Medicine Jichi Medical University
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Kajii Eiji
自治医科大学 地域医療学
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Ishikawa Suzukiyo
南郷村国民健康保険病院
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Ishikawa Shizukiyo
Division Of Community And Family Medicine Jichi Medical University School Of Medicine
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Matsumoto Masatoshi
Division Of Community And Family Medicine Centre For Community Medicine Jichi Medical University
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HATANO Yu
Sixth-year medical student, Jichi Medical University
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Mizooka Masafumi
Division Of Community And Family Medicine Centre For Community Medicine Jichi Medical University
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Hatano Yu
Sixth-year Medical Student Jichi Medical University
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Kajii Eiji
Division Of Community And Family Medicine Jichi Medical University
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Isikawa Sizukiyo
Department Of Cardiology Jichi Medical School
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