The Function of the Clock-Associated Transcriptional Regulator CCA1 (CIRCADIAN CLOCK-ASSOCIATED 1) in Arabidopsis thaliana

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概要

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• In the model higher plant Arabidopsis thaliana, the CCA1 (CIRCADIAN CLOCK-ASSOCIATED 1) gene plays important circadian clock-associated roles. The CCA1 protein is a member of a small subfamily of single MYB-related transcription factors. This family consists of several homologous CCA1-like transcription factors, including the closest homolog LHY (LATE ELONGATED HYPOCOTYL). To gain insight into the molecular function of CCA1 and its homologs, here we took a unique genetic approach that was recently developed for Arabidopsis thaliana. Through this strategy, referred to as CRES-T (Chimeric REpressor Silencing Technology), a transgenic plant was constructed to produce a dominant negative transcriptional repressor (designated CCA1-SRDX). By employing the resulting transgenic lines, together with previously established cca1 lhy double mutant and CCA1-ox (over-expressing) plants, their circadian clock-associated phenotypes were examined and compared with each other. The observed clock-associated phenotypes of the CCA1-SRDX plants were very similar to those of CCA1-ox, but not to those of cca1 lhy, suggesting that CCA1 acts predominantly as a transcriptional repressor in nature. However, the developmental morphology (or architecture) of adult CCA1-SRDX plants were quite different from that of CCA1-ox, suggesting that CCA1 might also be implicated, directly or indirectly, in an as yet unknown circadian-associated output pathway at a late developmental stage.

• 社団法人 日本農芸化学会の論文
• 2008-05-23

著者

• Ito Shogo

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• Nakamichi Norihito

  Division of Biological Science, Graduate School of Science, Nagoya University

• YAMASHINO Takafumi

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• MIZUNO Takeshi

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• Yamashino Takafumi

  Nagoya Univ. Nagoya Jpn

• Nakamichi Norihito

  Riken Yokohama Jpn

• Nakamichi Norihito

  Division Of Biological Science Graduate School Of Science Nagoya University

• Ito Shogo

  Nagoya Univ. Nagoya Jpn

• Mizuno Takeshi

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Yamashino T

  Nagoya Univ. Nagoya Jpn

• Mizuno Takeshi

  Lab. Of Molecular Microbiology School Of Agriculture Nagoya Univ.

• Mizuno T

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Mizuno T

  Lab. Of Molecular Microbiology School Of Agriculture Nagoya Univ.

• KOJIMA Masaya

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• Kawamura Masakazu

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• Yamashino Takafumi

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Ito Shogo

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Moritz Thomas

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Takeuchi Michio

  Department Of Applied Molecular Biology And Biochemistry Tokyo University Of Agriculture And Technol

• Kawamura Masakazu

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Mizuno Takeshi

  Laboratory Of Microbiology School Of Agriculture Nagoya University

• NAKAMICHI Norihito

  Graduate School of Bioagricultural Sciences, Nagoya University

• Mizuno T

  Faculty Of Agriculture Tokyo University Of Agriculture And Technology

• YAMASHINO Takafumi

  Laboratory of Molecular and Functional Cenomics, School of Agriculture, Nagoya University

• ITO Shogo

  Laboratory of Molecular and Functional Genomics, School of Agriculture, Nagoya University

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