Potencies of Phosphine Peptide Inhibitors of Mammalian Thimet Oligopeptidase and Neurolysin on Two Bacterial Pz Peptidases
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概要
- 論文の詳細を見る
Pz peptidases A and B, from a thermophile Geobacillus collagenovorans MO-1, recognize collagen-specific tripeptide units (Gly-Pro-Xaa). They share similarities in function but extremely low identities in primary sequence with mammalian thimet oligopeptidase (TOP) and neurolysin. Three phosphine peptide inhibitors that selectively inhibit TOP and neurolysin on two bacterial Pz peptidases were investigated. They showed potent inhibition of both Pz peptidases in a range from 10 to 100 nM.
- 社団法人 日本農芸化学会の論文
- 2007-02-23
著者
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Matsui Hiroshi
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
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Kawasaki Akio
Department of Cardiovascular Surgery, Teikyo University School of Medicine
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Watanabe Kunihiko
Department of Chemical Industry, Science University of Tokyo
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TSUJIMOTO Yoshiyuki
Department of Applied Biochemistry, Kyoto Prefectural University
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Tsujimoto Yoshiyuki
Division Of Applied Life Sciences Graduate School Of Life And Environmental Sciences Kyoto Prefectur
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SUGIHARA Yusuke
Department of Applied Biochemistry, Kyoto Prefectural University
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Kawasaki Akio
Department Of Applied Biochemistry Kyoto Prefectural University
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Sugihara Yusuke
Department Of Applied Biochemistry Kyoto Prefectural University
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Watanabe Kunihiko
Department Of Chemical Industry Science University Of Tokyo
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Matsui Hiroshi
Division Of Applied Life Sciences Graduate School Of Life And Environmental Sciences Kyoto Prefectur
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Watanabe Kunihiko
Division Of Applied Life Sciences Graduate School Of Life And Environmental Sciences Kyoto Prefectur
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Watanabe Kunihiko
Department Of Applied Biochemistry Kyoto Prefectural University
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