A Plant Growth Retardant, Uniconazole, Is a Potent Inhibitor of ABA Catabolism in Arabidopsis

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概要

• 論文の詳細を見る

• Plant growth retardants (PGRs) reduce the shoot growth of plants by inhibiting gibberellin biosynthesis. In this study, we performed detailed analyses of the inhibitory effects of PGRs on Arabidopsis abscisic acid (ABA) 8′-hydroxylase, a major ABA catabolic enzyme, recently identified as CYP707As. In an in vitro assay with CYP707A3 microsomes expressed in insect cells, uniconazole-P inhibited CYP707A3 activity more effectively than paclobutrazol or tetcyclacis, whereas the other PGRs tested did not inhibit it significantly. Uniconazole-P was found to be a strong competitive inhibitor (Ki=8.0 nM) of ABA 8′-hydroxylase. Uniconazole-P-treated Arabidopsis plants showed enhanced drought tolerance. In uniconazole-P-treated plants, endogenous ABA levels increased 2-fold as compared with the control, and co-application of GA4 did not suppress the effects, indicating that the effects were not due to gibberellin deficiency. Thus uniconazole-P effectively inhibits ABA catabolism in Arabidopsis plants. We also discuss the structure-activity relationship of the azole-type compounds on ABA 8′-hydroxylase inhibitory activity.

• 社団法人 日本農芸化学会の論文
• 2006-07-23

著者

• KAMIYA Yuji

  Plant Hormone Function, Frontier Research Program, RIKEN

• Shinozaki K

  Riken Ibaraki Jpn

• Kamiya Y

  Plant Science Center Riken

• Kamiya Y

  Riken Plant Science Center

• Mizutani Masaharu

  Institute for Chemical Research, Kyoto University

• Sakata Kanzo

  Institute for Chemical Research, Kyoto University

• Hirai Nobuhiro

  International Innovation Center Kyoto University

• Soeno Kazuo

  RIKEN Plant Science Center

• Kamiya Yuji

  Laboratory For Plant-hormone Function Frontier Research Program The Institute Of Physical And Chemic

• Kamiya Yuji

  Growth Regulation Research Group Riken Plant Science Center

• NAMBARA Eiji

  Plant Science Center, RIKEN (Institute of Physical and Chemical Research)

• KOSHIBA Tomokazu

  Department of Biological Sciences, Tokyo Metropolitan University

• Nambara E

  Hokkaido Univ. Sapporo Jpn

• Nambara Eiji

  Department Of Applied Bioscience Faculty Of Agriculture Hokkaido University:laboratory For Plant-hor

• Shinozaki Kazuo

  Tsukuba Institute (RIKEN)

• Todoroki Yasushi

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• Todoroki Yasushi

  Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University

• Kamiya Y

  Growth Regulation Research Group Riken Plant Science Center

• Mizutani Masaharu

  Institute For Chemical Research Kyoto University

• Kanno Yuri

  Department Of Bioresource Engineering Yamagata University

• Sakata Kanzo

  Institute For Chemical Research Kyoto University

• Komano Teruya

  Department Of Biological Sciences Tokyo Metropolitan University

• Shinoda Shoko

  Growth Regulation Research Group Riken Plant Science Center

• SAITO Shigeki

  Institute for Chemical Research, Kyoto University

• OKAMOTO Masanori

  Plant Science Center, RIKEN

• SHINODA Shoko

  Plant Science Center, RIKEN

• KUSHIRO Tetsuo

  Plant Science Center, RIKEN

• OKAMOTO Masanori

  Growth Regulation Research Group, RIKEN Plant Science Center

• Shinozaki Kazuo

  Lab. Of Pmb Riken

• Kushiro Tetsuo

  Growth Regulation Research Group Riken Plant Science Center

• Saito Shigeki

  Institute For Chemical Research Kyoto University

• Koshiba T

  Growth Regulation Research Group Riken Plant Science Center

• Sekimata Katuhiko

  Discovery Research Institute Riken

• Koshiba Tomokazu

  Department Of Bio!ogy Tokyo Metropolitan University

• Kamiya Yuji

  Plant Hormone Function Frontier Research Program Riken

• KAMIYA Yuki

  Faculty of Agriculture, Niigata University

• Okamoto Masanori

  Department Of Biological Sciences Tokyo Metropolitan University

• Tatematsu Kiyoshi

  National Inst. Basic Biology Okazaki Jpn

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