複合体結晶構造から見た尿酸生成抑制剤のキサンチン酸化還元酵素阻害機構の検討

スポンサーリンク

概要

• 論文の詳細を見る
• 2003-07-01

著者

• 西野 武士

  日本医科大学大学院医科生物化学分野

• 西野 朋子

  Department Of Biochemistry And Department Of Molecular Biology Nippon Medical School

• Nishino Takeshi

  日本医科大学 医科生物科学

• 岡本 研

  日本医科大学・医学部・生化学(第一)

• Nishino T

  Department Of Biochemistry And Engineering Faculty Of Engineering Tohoku University

• Nishino Tokuzo

  Dep. Of Biochemistry And Engineering Fac. Of Engineering Tohoku Univ.

• Pai E.

  トロント大医学部

• 岡本 研

  日本医科大学大学院医科生物化学分野

• 岡本 研

  日本医科大学 生化学第1教室

• 岡本 研

  日本医科大学生化学分子生物学講座(構造生物学・代謝学)

• Eger Bryan

  Dept. Of Biochemistry University. Of Toronto

• 西野 武士

  日本医科大学 第1生化

• 西野 朋子

  日本医科大学大学院・医科生物化学

• PAI Emil

  Dept. of Biochemistry, University. of Toronto

• Nishino Takeshi

  Dept Of Biochem Univ Of California Riverside Usa

• Nishino Takeshi

  Department Of Microbiology Kyoto Pharmaceutical University

• Okamoto Ken-ichi

  Graduate School Of Pure And Applied Sciences University Of Tsukuba

• Okamoto Ken-ichi

  Department Of Chemistry Graduate School Of Pure And Applied Sciences University Of Tsukuba

• Okamoto Ken-ichi

  Department Of Advanced Materials Science And Engineering Faculty Of Engineering Yamaguchi University

• 西野 武士

  Dept. of Biochem., Univ. of California

• Okamoto Kouji

  Department Of Biochemical Engineering And Science Kyusyu Institute Of Technology

• Okamoto Ken

  Department Of Biochemistry And Molecular Biology Nippon Medical School

関連論文

• 生化学特集「タンパク質の化学構造から生物機能に迫る」
• 妊娠中毒症胎盤おける一酸化窒素合成酵素活性の検討(一般演題:ポスター)
• 組換え体を用いたヒト・キサンチン酸化酵素の結晶化と構造解析
• 3SC54 キサンチン脱水素酵素におけるモリブデン水酸化反応中間体の構造と反応機構(金属タンパク質のメカニズムを観察する)
• 活性部位変異体を用いたキサンチン酸化酵素基質特異性の変化
• ヒトキサンチン脱水素酵素の大腸菌を用いた発現及び基質特異性認識機構の解析
• キサンチン尿症 type II の原因遺伝子
• S72 生理活性物質NOとその生体内における合成制御 : NO合成酵素はいかにして調節されているか?
• 部位特異的変異法及び, 結晶構造から解析したキサンチン脱水素酵素の酸化酵素型への変換機構
• キサンチン脱水素酵素における鉄硫黄中心
• 部位特異的変異によるキサンチン脱水素酵素の脱水素酵素型, 酸化酵素型相互変換機構の解析
• Xenopus翻訳開始因子eIF-4Eの発現及びその機能
• 発現した非ヘム鉄欠失キサンチン脱水素酵素の性質
• メルカプトピルビン酸硫黄転移酵素はロダネーゼのファミリー酵素だった
• 新規キサンチン酸化還元酵素阻害剤FYX-051の作用機序に関する酵素学的, 構造生物学的解析
• 3P031 哺乳類のキサンチン脱水素酵素とバクテリア由来のキサンチン脱水素酵素との間における動的構造の差異(蛋白質(構造・構造機能相関),ポスター発表,第45回日本生物物理学会年会)
• 複合体結晶構造から見た尿酸生成抑制剤のキサンチン酸化還元酵素阻害機構の検討
• キサンチン脱水素酵素、酸化酵素の結晶構造
• モリブデンによる水酸化反応中間体の構造と反応機構
• Two Mutations Convert Mammalian Xanthine Oxidoreductase to Highly Superoxide-productive Xanthine Oxidase
• 酵素のかたちにあわせた痛風治療薬 (特集 タンパク質のかたちと病気)
• キサンチン脱水素酵素のかたちとそれにあわせた痛風治療薬
• キサンチン脱水祖酵素の各種阻害剤の解析結果から見た酵素の性質と反応機能
• キサンチン脱水素酵素から酸化酵素への蛋白質構造・機能の変換の分子機構--蛋白質のコンフォメーションスイッチとリレー系
• Purification and Characterization of Multiple Forms of Rat Liver Xanthine Oxidoreductase Expressed in Baculovirus-Insect Cell System
• 結晶構造から解析したキサンチン脱水素酵素の酸化酵素型への変換機構
• Overexpression of an Archaeal Geranylgeranyl Diphosphate Synthase in Escherichia coli Cells
• Identification of Genes Affecting Lycopene Formation in Escherichia coli Transformed with Carotenoid Biosynthetic Genes: Candidates for Early Genes in Isoprenoid Biosynthesis
• Recognition of Allylic Substrates in Sulfolobus acidocaldarius Geranylgeranyl Diphosphate Synthase: Analysis Using Mutated Enzymes and Artificial Allylic Substrates^1
• Effects of Random Mutagenesis in a Putative Substrate-Binding Domain of Geranylgeranyl Diphosphate Synthase upon Intermediate Formation adn Substrate Specificity^1
• 学術 基礎医学から 痛風治療薬としての尿酸生成酵素阻害剤
• 抗痛風薬の1つの利用法を例に本学会を考える
• Primary Structure and Catalytic Properties of a Cold-active Esterase from a Psychrotroph, Acinetobacter sp. Strain No.6. Isolated from Siberian Soil(Biochemistry & Molecular Biology)
• Cold-Active Lipolytic Activity of Psychrotrophic Acinetobacter sp. Strain No.6
• Gene Cloning and Overexpression of a Geranylgeranyl Diphosphate Synthase of an Extremely Thermophilic Bacterium, Thermus thermophilus
• Selective Formation of Alkoxo-bridged Titanium(IV) Polynuclear Complexes with Polyaminopolycarboxylate : First Titanium(IV) Octanuclear Complex Containing Cubic-type {Ti_4(μ-oxo)_4}_2(μ-alkoxo)_4 Core
• On the Development of Naphthalene-Based Sulfonated Polyimide Membranes for Fuel Cell Applications
• Preparation and Gas Permeation Properties of Composite Carbon Molecular Sieve Membranes Derived from Polyimides with Thermally Decomposable Sulfonic Acid Salt and/or Hexafluoroisopropylidene Group
• Synthesis and Gas Permeation Properties of Star-like Poly(ethylene oxide)s Using Hyperbranched Polyimide as Central Core
• Synthesis and Characterization of Polyimides with Pendant Phosphonate Ester Groups
• Migration of ortho-Positronium in Polymer Films
• Carbon Molecular Sieve Membrane Prepared from Phenolic Resin
• Selective Permeation of Carbon Dioxide through Amine-modified Polyimide Membranes
• The Effects of CO_2-Conditioning of Polymers on Positron Annihilation and Gas Permeation Properties
• PERVAPORATION-AIDED ESTERIFICATION OF OLEIC ACID
• Selective Permeation of Carbon Dioxide over Nitrogen through Polyethyleneoxide-Containing Polyimide Membranes
• VAPOR-PERMEATION SEPARATION OF WATER-ETHANOL MIXTURES BY ASYMMETRIC POLYIMIDE HOLLOW-FIBER MEMBRANE MODULES
• 1P-053 キサンチン脱水素酵素の分子動力学研究 : キサンチン脱水素酵素とそのインヒビターとの相互作用(蛋白質・構造機能相関(1),第46回日本生物物理学会年会)
• 2P142 Dynamic structure of xanthine oxidoreductase by normal mode analysis(33. Redox enzyme,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
• Phylogenetic Position of Kinetoplastid Protozoa Inferred from the Protein Phylogenies of Elongation Factors 1α and 2^1
• Pepstatin A, an Aspartic Proteinase Inhibitor, Suppresses RANKL-Induced Osteoclast Differentiation
• Characterization of Phagosomal Subpopulations along Endocytic Routes in Osteoclasts and Macrophages
• 3P031 分子動力学によるキサンチン酸化還元酵素と阻害剤の相互作用の研究(蛋白質-構造機能相関,第48回日本生物物理学会年会)
• Structural Change in Elastin Model Peptides upon Interaction with Biologically Important Metal Ions
• 3P-023 Febuxostatとキサンチン脱水素酵素の鍵と鍵穴機構におけるタンパク質の揺らぎの重要性(蛋白質-構造機能相関,第47回日本生物物理学会年会)
• 一酸化窒素によるキサンチン酸化酵素の阻害機構
• Inhibition of Neuronal Nitric Oxide Synthase by Phosphatidylinositol 4, 5-Bisphosphate and Phosphatidic Acid
• 結晶構造から見たキサンチン酸化還元酵素阻害剤の阻害機構の解明
• Chemotactic and Proliferative Responses of Vascular Smooth Muscle Cells to Elastin-derived Peptides
• Substrate Specificities of Several Prenyl Chain Elongating Enzymes with Respect to 4-Methyl-4-pentenyl Diphosphate
• An Artificial Substrate for the Thermostable Farnesyl Diphosphate Synthase from Bacillus stearothermophilus
• X-Ray Absorption Spectroscopic Analysis of the High-Spin Ferriheme Site in Substrate-Bound Neuronal Nitric-Oxide Synthase^1
• Sequence Motif-Specific Assignment of Two [2Fe-2S] Clusters in Rat Xanthine Oxidoreductase Studied by Site-Directed Mutagenesis
• Binding Analysis of Xenopus laevis Translation Initiation Factor 4E (eIF4E) in Initiation Complex Formation
• バキロウイルス発現系によるキサンチン脱水素酵素の蛋白翻訳後の機能発現
• The Regulation of Bone Resorption in Tooth Formation and Eruption Processes in Mouse Alveolar Crest Devoid of Cathepsin K
• Gingipains Inactivate a Cell Surface Ligand on Porphyromonas gingivalis That Induces TLR2- and TLR4-Independent Signaling
• Complete Nucleotide Sequences of the Genes Encoding Translation Elongation Factors 1α and 2 from a microsporidian parasite, Glugea plecoglossi: Implications for the Deepest Branching of Eukaryotes
• Structural Profiles for Coacervation of Elastin-derived Polypeptides
• Rapid Degradation of Cathepsin E in Pre-Golgi Compartments after Tunicamycin Treatment
• Mutational Analysis of the Role of His452 of Saccharopolyspora rectivirgula β-Galactosidase
• Human Xanthine Oxidase Changes its Substrate Specificity to Aldehyde Oxidase Type upon Mutation of Amino Acid Residues in the Active Site : Roles of Active Site Residues in Binding and Activation of Purine Substrate
• Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient macrophages.
• Cathepsin E-Deficient Mice Show Increased Susceptibility to Bacterial Infection Associated with the Decreased Expression of Multiple Cell Surface Toll-Like Receptors
• Association of Cathepsin E Deficiency with Development of Atopic Dermatitis
• Porphyromonas gingivalis Proteinases as Virulence Determinants in Progressin of Periodonatal Diseases
• Biochemical and Functional Properties of Lysine-Specific Cysteine Proteinase(Lys-Gingipain)as a Virulence Factor of Porphyromonas gingivalis in Periodontal Disease^1
• Cloning and Sequencing of the Gene Encolding a Novel Lysine-Specific Cysteine Proteinase (Lys-Gingipain)in Porphyromonas gingivalis: Structural Relationship with the Arginine-Specific Cysteine Proteinase(Arg-Gingipain)
• Elastin-derived Peptides : Structure, Functions and Mechanisms
• RECEPTOR-MEDIATED BINDING OF ELASTIN-DERIVED HEXAPEPTIDE TO MACROPHAGES INDUCED A GALACTOSUGAR-SENSITIVE CHEMOTAXIS
• Comparison of Chemotactic Activity of Macrophages Induced by Permutations of Elastin-derived Hexapeptide VGVAPG and Pentapeptide VGVPG
• Chemotactic Activation of Macrophages by Elastin Hexapeptide Sequences and Its Signaling Mechanism
• Elastin Peptide-Induced Macrophage Chemotaxis and Its Signal Transduction Pathway
• Involvement of Intracellular Cyclic GMP and Cyclic GMP-Dependent Protein Kinase in α-Elastin-Induced Macrophage Chemotaxis
• Alterations of susceptibility of Pseudomonas aeruginosa by overproduction of multidrug efflux systems, MexAB-OprM, MexCD-OprJ, and MexXY/OprM to carbapenems : substrate specificities of the efflux systems
• Diffusion of macrolide antibiotics through the outer membrane of Moraxella catarrhalis
• Molecular Cloning and Characterization of the oprQ Gene Coding for Outer Membrane Protein OprE3 of Pseudomonas aeruginosa
• 2.キサンチン酸化酵素の構造と機能 : ビタミンB研究委員会平成8年度シンポジウム : キノプロテインとフラビン酵素研究の新展開
• Up-regulation, Enhanced Maturation, and Secretion of Cathepsin E in Mouse Macrophages Treated with Interferon-γ or Lipopolysaccharide
• The Role of the Cathepsin E Propeptide in Correct Folding, Maturation and Sorting to the Endosome
• Mutational Analysis of Residues in Two Consensus Motifs in the Active Sites of Cathepsin E
• Design and Synthesis of Sensitive Fluorogenic Substrates Specific for Lys-Gingipain^1
• 新旧高尿酸血症の治療薬
• 新規尿酸生成阻害剤を用いた治療戦略
• キサンチン脱水素酵素の構造と機能に関する研究 : desulfo 型酵素の存在とその分離法精製法の確立と生理・病態的意義
• 尿酸生成酵素の構造, 機能, 調節と阻害剤
• 豊かで寛容な精神
• Substrate Specificities of Wild and Mutated Farnesyl Diphosphate Synthases from Bacillus Stearothermophilus with Artificial Substrates
• 26pPSB-32 キサンチン酸化還元酵素における阻害剤の作用の研究 : 「鍵と鍵穴」のドグマを超えて(26pPSB 領域12ポスターセッション,領域12(ソフトマター物理,化学物理,生物物理))
• 24aPS-22 キサンチン酸化還元酵素に対するフェブキソスタットの阻害作用(24aPS 領域12ポスターセッション,領域12(ソフトマター物理,化学物理,生物物理))

もっと見る 閉じる

スポンサーリンク